05). Anti-HEV positivity was not associated with race, sex, ethnicity, country of birth and primary language. Conclusion: Seroprevalence of HEV increased with age and was higher in patients with chronic liver disease of viral etiology compared to other etiologies. There is considerable variation in the seroprevalence of HEV depending on the assay used, ranging from 14%-26% among chronic liver disease patients- similar to the general U.S. population. Wantai and NIH assays had the highest inter-test concordance. Understanding test performance characteristics of these assays is crucial to see more the interpretation of HEV prevalence. Comparison
of 3 assays P value: a vs d = 0.0003, b vs d = 0.3, b vs c = 0.4 Disclosures: The following people
have nothing Raf activity to disclose: Niharika Samala, Elizabeth C. Wright, Joni Trenbeath, Ronald E. Engle, Nancy Fryzek, Harvey J. Alter, Jay H. Hoofnagle, Marc G. Ghany The impact of liver diseases (LDs) on health-related quality of life (HRQoL) is an important aspect to understand the burden of these conditions and to improve their management. A well characterized impact of the major LDs on HRQoL of the general population is still lacking. The aim of our study was to fill this gap. A dataset with HRQoL data of a representative sample of the general population of most populated Italian region was matched with the dataset from a multicenter study conducted selleck chemicals in the same region and
time period to generate and validate a set of health care outcomes indicators for the major LDs (hepatitis B (HBV), hepatitis C (HCV), compensated cirrhosis (CC), decompensated cirrhosis (DC), hepatocellular carcinoma (HCC), autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), NAFLD/ NASH and patients listed for liver transplant (LTL)). Within both datasets, HRQoL data were collected using the EQ-5D-3L, a generic instrument that enables HRQoL to be compared within and between clinical conditions and with the general population. It generates a health profile made up of 5 domains (Mobility, Self-care, Usual activities, Pain/discomfort, Anxiety/ depression). It also consists of a visual analogue scale (EQ-5D VAS) which measures overall HRQoL. Further, results from the EQ-5D health profile can be converted to utility index, useful to conduct economic evaluations. Multivariate logistic and linear regressions were then performed adjusting for possible confounders (age, sex, education and working status). A total of 6,800 “healthy subjects” and 3,105 subjects with LDs (625 HCV, 287 HBV, 614 CC, 531 DC, 647 HCC, 59 LTL, 229 NAFLD/NASH, 68 PBC, 55 PSC, and 49 AIH) were included in the analyses. Multivariate logistic analyses showed that DC, HCC, and LTL had significantly (p<0.05) higher risk to have problems in mobility, self-care, and usual activities compared to “healthy subjected”.