, 2007). Borchers A.T., Davis P.A. and Gershwin E. (2004). The Asymmetry of Existence: Do We Owe Our Existence to Cold Dark Matter and the Weak Force?, Experimental Biology and Medecine, 229(1): 21–32. Bredehft J. H., Breme K., Meierhenrich U. J., Hoffmann S.V. MDV3100 research buy and Thiemann W. H.-P. (2007). Chiroptical Properties of Diamino Carboxylic Acids. Chirality, 19:570–573. Jordan I.K., Kondrashov F.A., Adzhubei I.A., Wolf Y.I., Koonin E.V., Kondrashov A.S. and Sunyaev S. (2005). A universal trend of amino acid gain and loss in protein evolution, Nature, 433:633–638.

Meierhenrich U. J., Muoz Caro G.M., Bredehft J.H., Jessberger E.K. and Thiemann W. H.-P. (2004). Identification of diamino acids in the Murchison meteorite, Proceedings of the National Academy of Sciences of the

United States of America, CB-839 molecular weight 101(25):9182–9186. Meierhenrich U. J. and Thiemann W. H.-P. (2004). Photochemical concepts on the origin of biomolecular asymmetry, Origins of Life and Evolution of the Biosphere, 34:111–121. Nelson K. E., Levy M. and Miller S. L. (2000). Peptide nucleic acids rather than RNA may have been the first genetic molecule, Proceedings of the National Academy of Sciences of the United States of America, 97(8): 3868–3871. E-mail: scotto@unice.​fr A Model for Asymmetric Amino Acid Photolysis Jan Hendrik Bredehöft1, Uwe J. Meierhenrich2, Katharina Breme2, Jun-ichi Takahashi3, Wolfram H.-P. Thiemann4, Søren V. Hoffmann5 1The Open University, Physics & Astronomy, Walton Hall, Milton Keynes, MK7 6AA, United Kingdom;

2University of Nice-Sophia Antipolis, CNRS UMR 6001, avenue Valrose, 06108 Nice, France; 3NTT Microsystem Integration Laboratories, 3-1, Morinosato Wakamiya, Atsugi 243-0198, Japan; 4University of Bremen, Dept. of Physical Chemistry, Leobener Straβe, 28359 Bremen, Germany; 5University of Aarhus, Selleckchem AZD3965 Institute for Storage Ring Facilities, Ny Munkegade, 8000 Aarhus C, Denmark All biopolymers rely on a specific handedness of their building blocks, so the question of symmetry breaking occurs naturally when one tries to understand the origin and formation history of these biopolymers. It does so especially in Guanylate cyclase 2C proteins and their monomer building blocks, amino acids, since a very large number (90) of the latter are known to be found in extraterrestrial sources such as meteorites (Bredehöft and Meierhenrich in press). Some of these amino acids, clearly of non-biological origin, show an excess of one enantiomer over the other (Pizzarello and Cronin 2000). One of the mechanisms discussed for triggering this break of symmetry is asymmetric photochemistry in interstellar/ circumstellar matter by means of circularly polarized light (Bailey et al. 1998, Lucas et al. 2005, Buschermöhle et al. 2005, Meierhenrich et al. 2005). A very powerful tool for the study of the molecules that undergo such photochemical reactions is Circular Dichroism Spectroscopy.