All these results remind us that drug-drug interaction should be paid much attention when developing celastrol as a promising anti-tumor agent.”
“The purpose of this retrospective analysis is to determine whether disc prosthesis replacement can be equivalent or superior compared with the disc interbody fusion.
Between January, 2005 and June, 2011 we performed microdiscetomy by the anterior approach in 176 patients. We subdivided the total set of patients into two groups. Group A is made up of 84 patients in whom the prosthetic disc was implanted; Group B is made up of 92 patients in whom disc fusion was performed.
In both groups, the radicular pain disappeared and the signs
of spinal cord compression improved or remained stable. Patients of Group A required significantly fewer days of hospitalization and shorter absence from work, and had significant lower scores in the Neck Disability Index (NDI) at 12 KPT-8602 concentration months.
Our
experience demonstrates that the use of disc prosthesis is a safe and effective alternative to interbody fusion.”
“Irrational prescribing practice of antibiotics is an alarming threat which is associated Proteasomal inhibitors with potential risk for patient as well as for whole community. The aim of this questionnaire based survey study is to assess the physicians’ behavior and knowledge regarding the prescription of antibiotics. This study was conducted during January 2012 in Abbottabad, Pakistan. A sample of 120 physicians was selected by stratified sampling technique. Data was entered and analyzed using SPSS version 16.0. Out of 120 physicians, 116 participated in the study. Out of 116 participants, 82.76
% prescribe antibiotics without any diagnostic test. A total of 81.9 % participants do not perform hypersensitivity test. Out of total, 12.93 % participants do not have any idea about microbial resistance. Furthermore, 81.03 % participants see more do not follow up patient compliance whereas 47.41 % do not consider cost effectiveness. Not a single participant consults a pharmacist during medication prescription. The prescribing practice in our findings is not in accordance with the rational prescribing guidelines.”
“Surgical management of upper cervical spine (UCS) unstable injuries may be challenging as the number of cases requiring this surgery collected in every single center is small. This retrospective study was conducted to analyze the radiographic and clinical results in 12 patients undergoing a posterior occipito-cervical fusion by a polyaxial screws-rod-plate system.
There were eight male and four female patients with a mean age of 73.7 years (range 32-89 years). Six patients presented neurologic deficits at admission. Six patients had sustained major trauma. The remaining six patients had suffered a minor trauma.
Two patients died postoperatively in Intensive Care Unit.