animals demonstrating mechanical hyperalgesia were randomly assigned to either HBO treatment or control for 90 thin treatment sessions. after which mechanical sensitivity was assessed at 15 min and 6 h post Daily HBO sessions. with assessments 15 min post-treatment, continued for two weeks, followed by 5 days of assessment only. The results indicated that both models demonstrated significant improvement in response to treatment over the course of the two-week period, with CCI animals recovering
PLX4032 more quickly and maintaining this recovery throughout the post-treatment period. Hyperbaric oxygen treatment appears to be successful in relieving neuropathic pain for an extended period of time, anti future research should be aimed at investigating the precise mechanisms underlying this positive effect (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved”
“Purpose: Roux-en-Y gastric bypass surgery has become an increasingly common form of weight management. Early retrospective reviews have suggested that new onset nephrolithiasis develops in some patients after undergoing Roux-en-Y gastric bypass. We present a prospective
longitudinal selleck chemical study to assess risk factors for nephrolithiasis after Roux-en-Y gastric bypass.
Materials and Methods: A total of 45 morbidly obese patients scheduled to undergo Roux-en-Y gastric bypass surgery were enrolled in this prospective study between November 2006 and November 2007. Exclusion MRIP criteria included history of nephrolithiasis or inflammatory bowel disease. Serum uric acid, parathyroid hormone,
calcium, albumin, and creatinine and 24-hour urine collections were obtained within 6 months before Roux-en-Y gastric bypass, and at 6 to 12 months postoperatively. A Wilcoxon signed-rank test was used to compare preoperative and postoperative serum laboratory values and 24-hour urine values. McNemar’s test was used to determine if the percent of abnormal values underwent a statistically significant change after Roux-en-Y gastric bypass. For both statistical methods a p value was calculated for the change in each variable with p <0.05 considered statistically significant.
Results: Statistically significant changes included increased urinary oxalate and calcium oxalate supersaturation, and decreased urinary citrate and total urinary volume postoperatively. A statistically significant percentage of patients exhibited decreased urinary calcium, while a statistically significant percentage of patients experienced increased urinary oxalate and calcium oxalate supersaturation.
Conclusions: Our prospective study demonstrated multiple factors that increase the relative risk of nephrolithiasis after Roux-en-Y gastric bypass. These changes may make stone formation after Roux-en-Y gastric bypass increasingly likely and pose an ongoing challenge in the realm of urology.