cyst; 4. adult; Presenting Author: ZHONG GAO WANG Additional Authors: ZHI WEI HU, JI MIN WU, JIAN JUN LIU, YU ZHANG, SHU RUI TIAN, GUANG CHANG ZHU, WEI TAO LIANG Corresponding Author: ZHONG GAO WANG Affiliations: Center for GERD, General Hospital of Second Artillery; Xuanwu Ivacaftor Hospital of Capital Medical University Objective: Childhood-to-adult persistent asthma is usually considered to be an atopic disease. However gastroesophageal reflux disease (GERD) may also play an important role in this phenotype of asthma. Methods: An investigation of 57 consecutive patients with decades of childhood-to-adult persistent asthmatic symptoms which were refractory to pulmonary medication.

GERD was assessed by endoscopy, reflux monitoring and manometry, and treated by Stretta radiofrequency (SRF) or laparoscopic Nissen fundoplication (LNF). The outcomes were followed up in January Autophagy inhibitor mw 2013 for an average of 3.3 ± 1.1 years. Results: Evident typical GERD symptoms, pathological acid reflux, and esophagitis were found in 51.9%, 64.9% and 47.4% of the patients. Meanwhile, Hiatus hernia (HH) was shown in 35.1% of the

patients; upper esophageal sphincter (UES) hypotonia, lower esophageal sphincter (LES) hypotonia, shortened LES and esophageal body dyskinesia were demonstrated by esophagus manometry in 50.9%, 43.9%, 35.1% and 45.6% of the patients respectively. The symptom score of heartburn, regurgitation, coughing, wheezing and chest tightness significantly decreased (P < 0.001) from 5.8 ± 2.0, Fluorouracil manufacturer 5.6 ± 2.0, 7.3 ± 1.6, 8.4 ± 1.2 and 8.1 ± 1.5 to 1.2 ± 1.8, 1.1 ± 1.6, 2.8 ± 2.5, 3.8 ± 2.7 and 3.9 ± 2.7 respectively after anti-reflux treatment. Cure, excellent, and good outcome in the overall asthma status were obtained in 7.0%, 31.6%

and 26.3% of the patients, while 21.1% and 14.0% of the patients had fair and poor response to the anti-reflux treatment. Conclusion: The prevalence esophagus dysfunction is high in GERD related childhood-to-adult persistent asthmatic patients who had inadequate response to medical treatment for asthma. The SRF and LNF are both effective in esophagus symptoms as well as GERD related persistent asthmatic symptoms. Evaluating the asthmatic patients for possible treatment of the underlying cause such as GER may improve symptoms and prevent disease persistency. Key Word(s): 1. GERD; 2. asthma; 3. radiofrequency; 4. fundoplication; Presenting Author: WEI LI Additional Authors: HUANONG LU Corresponding Author: HUANONG LU Affiliations: the First Affiliated Hospital of NanChang University Objective: Helicobacter pylori (H.pylori) is a major inducement of peptic ulcers, intestinal metaplasia (IM), dysplasia and gastric carcinoma (GC), whereas the exact pathological mechanism is still unknown. The present study was undertaken to determine possible pathological role of H.pylori in DNA damage response and repair pathways by establishing a H.pylori infected Mongolian gerbil model. We verified the hypothesis that chronic H.