Findings Overall, suboptimum health increased with age. However, between the year before retirement and the year after, the estimated prevalence of suboptimum health fell from 19.2% (95% CI 18.5-19.9) to 14.3% (13.7-14.9), corresponding to a gain in health of 8-10 years. We noted this retirement-related improvement in men (odds ratio 0.68, 95% CI 0.64-0.73) and women (0.74,
0.67-0.83), and across occupational grades (low 0.72, 0.63-0.82; high 0.70, 0.63-0.77), and it was maintained throughout the 7 years after retirement. A poor work environment and health complaints before retirement were associated with a steeper yearly increase in the prevalence of suboptimum health while still in work, and a greater retirement-related improvement; however, people with a combination of high occupational grade, low demands, Roscovitine in vivo Sonidegib clinical trial and high satisfaction at work showed no such retirement-related improvement.
Interpretation These findings suggest that the burden of ill-health, in terms of perceived health problems, is substantially relieved by retirement for all groups of workers apart from those
with ideal working conditions, and that working life for older workers needs to be redesigned to achieve higher labour-market participation.”
“Numerous lines of research indicate that attentional processes, working memory and saccadic processes are highly interrelated. In the current study, we examine the relation between these processes with respect to their cognitive-neurophysiological and neurobiological background by means of event-related potentials (ERPs) in a sample of N=72 healthy probands characterized for the functional serotonin receptor 1 A (5-HT1A) C(-1019)G polymorphism.
The results
support a close interrelation between working memory, attentional and saccadic processes. Yet, these processes are differentially modulated by the 5-HT1A C(-1019)G polymorphism. The 5-HT1A C(-1019)G polymorphism primarily affects attentional processing, whereas processes related to the mental rotation of an object are independent of 5-HT1A genetic variation. It is shown that an increasing number of -1019 G alleles leads to a differential reduction of the N1 above the left and selleck products right hemisphere and hence bottom-up attentional processing. In the way increasing numbers of -1019 G alleles lead to a reduction of attentional processes, saccadic activity increases as a similar function of the number of -1019 G alleles. This increase in activity occurs parallel in time to the process of mental rotation. It is hypothesized that decreased attentional processes, dependent on different 5-HT1A C(-1019)G genotypes, may cause parietal networks to increase saccadic activity in order to perform mental rotation. (C) 2009 Elsevier Ltd. All rights reserved.”
“Background Neck pain is a common and costly condition for which pharmacological management has limited evidence of efficacy and side-effects.