PubMed 84. Briand J, Blehaut H, Calvayrac R, Laval-Martin D: Use of a microbial model for the determination Dorsomorphin chemical structure of drug effects on cell metabolism and energetics: study of citrulline-malate. Biopharmaceutics & drug disposition 1992,13(1):1–22.CrossRef 85. Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ: Citrulline/malate promotes aerobic energy production in human exercising muscle. British journal of sports medicine 2002,36(4):282–289.PubMedCrossRef 86. Brekhman II, Dardymov IV: New substances of plant origin which increase nonspecific resistance. Annual review of

pharmacology 1969, 9:419–430.PubMedCrossRef 87. Abidov M, Grachev S, Seifulla RD, Ziegenfuss TN: Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bulletin

of experimental biology and medicine 2004,138(1):63–64.PubMedCrossRef 88. Maslova LV, Kondrat’ev B, Maslov LN, Lishmanov Iu B: [The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress]. Eksperimental’naia i klinicheskaia farmakologiia 1994,57(6):61–63.PubMed 89. Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G: A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003,10(2–3):95–105.PubMedCrossRef 90. De Bock K, Eijnde Selleck Romidepsin BO, Ramaekers M, Hespel P: Acute Rhodiola rosea intake can improve endurance exercise performance. International journal of sport nutrition and exercise metabolism 2004,14(3):298–307.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions AES was the primary author of the manuscript and played an important role in study design, data collection and assessment. DHF and KLK played an important role in data collection and manuscript preparation. JRS was the senior author and played an important role in the grant procurement, study design, data analysis and manuscript preparation. All authors have read and approved the final manuscript.”
“Background

Creatine is predominantly situated in skeletal muscle, and originates Protirelin from both endogenous de novo synthesis and exogenous sources, which are mainly animal products [1]. Creatine and its phosphorylated form are well recognized as key intermediates in the energy metabolism of muscle fibres. Supplementation of creatine has been widely used among athletes as a means for increasing muscle mass and muscle strength and muscle endurance [2–4], but also for elderly people creatine supplementation, seems to enhance muscle strength [5]. The rationale behind CMH supplementation is to increase the content of creatine phosphate in the muscle, and several studies have also shown that the creatine content of the muscle is increased [6], and the majority of this is as creatine phosphate [1, 2].