3% were female. Etiology of liver fibrosis were 46.9% HBV, 15.6% HCV and 37.5% miscellanous. Results of Spearman rank test

level of hyaluronic acid (r = 0.436; p = 0.014), YKL-40 (r = 0.43; p = 0.014), Type IV collagen (r = 0.509; p = 0.003), laminin (r = 0.733; p = 0.001). Double linear regression test with stepwise method on all of the determinant factors show that the most significant determinant factor was type IV collagen (r = 0.463; p < 0.001). Conclusion: There was significant positive correlation between serum extracellular matrix (hyaluronic acid, laminin, YKL-40, type IV collagen) and liver stiffness in liver fibrosis patients. The most significant determinant factor was type IV collagen. Key Word(s): 1. liver stiffness; 2. liver fibrosis; 3. serum extracellular matrix (hyaluronic acid, laminin, Ykl-40, Type Iv collagen)

Presenting Author: XIU QING WEI Additional Authors: JIN TAO, ZUOFU WEN, BIN WU Corresponding Author: XIUQING WEI Affiliations: The Third Affiliated Hospital of Sun learn more Yat-Sen University; Third Affiliated Hospital, Sun Yat-Sen University; The Third Affiliated Hospital of Sun Yat-Sen Unive Objective: To introduce an uncommon cause of anorexia and jaundice. Methods: The medical course of a rare patient with anorexia and jaundice was presented in brief. Results: A 65-year-old woman was admitted to our hospital because of fatigue, anorexia and food avoidance during the past 6 months and jaundice for one month. Serum level of AST, ALT, total bilirubin and direct bilirubin tuclazepam were elevated at 174 U/L, 89 U/L , 163.9 umol/L and 117.9 umol/L respectively. Testes for serum cortisol level at the following time points: 0 am 76.67 nmol/L, 8 am 42.12 nmol/L,

4 pm 74.23 nmol/L, and ACTH was markedly low at 1.23 pmol/L. Hormones on other pituitary axes were within normal range. The patient responded quickly to hydrocortision and all the symptoms relieved totally one month later. Conclusion: Addision’s disease can be presented as hepatitis and anorexia in some rare cases. Key Word(s): 1. Addision’s disease; 2. hepatitis Presenting Author: MUSTOKO NEGORO WIBOWO Additional Authors: ARITANTRI DAMAYANI, PAULUS KUSNANTO, TRIYANTA YULI PRAMANA, TANTORO HARMONO Corresponding Author: MUSTOKO NEGORO WIBOWO Affiliations: Fk Uns – Dr Moewardi Hospital, Fk Uns – Dr Moewardi Hospital, Fk Uns – Dr Moewardi Hospital, Fk Uns – Dr Moewardi Hospital Objective: The aim of our study was to evaluate a possible correlation between HBV DNA, HCV RNA viral load and liver fibrosis assessed by Fibroscan among chronically infected subject Methods: Restrospective analysis of 64 patients with hepatitis B and hepatitis C undergoing Fibroscan in Dr. Moewardi Hospital Surakarta from January 2012 to March 2014. Statical analysis with Chi Square Test. Exclusion criteria were the presence of diabetes mellitus, advanced cancer and pregnancy.