Genetic studies have been carried out to assess variants in candidate genes, as well as polymorphisms throughout the genome, for their associations with heritable clinical outcomes of cystic fibrosis (CF), such as lung disease, meconium ileus, and CF-related diabetes. The candidate gene approach has identified some predicted relationships, while genome-wide surveys
have identified several genes that would not have been obvious disease-modifying candidates, such as a methionine sulfoxide transferase gene that influences intestinal obstruction, or a region on chromosome 11 proximate to genes encoding a transcription factor and an apoptosis controller Proteasome inhibitor drugs that associates with lung function. These unforeseen associations thus provide novel insight into disease pathophysiology, as well as suggesting new therapeutic strategies for CF.”
“In order to achieve the objectives of the European Union’s Water Framework Directive (WFD) for assessing chemical contamination of water bodies [i.e. checking compliance with Environmental Quality Standards (EQSs) for priority substances (PSs), and monitoring trends of contamination],
it is necessary to propose reliable methodologies for monitoring micropollutants. For hydrophobic substances, this involves the use of integrative matrices (e.g., biota or sediment).
We discuss here the implementation and the feasibility of a large-scale chemical biomonitoring approach for continental waters, considering the LXH254 clinical trial benefits and the limitations of existing biomonitoring strategies, the factors that can affect data interpretation, and the choice of CDK inhibitor species with regard to the WFD. Current scientific knowledge shows that, unlike the marine environment, continental waters have only a few established and standardized biomonitoring methodologies.
From the literature reviewed, active approaches to biomonitoring (using transplanted organisms) appear to be more suitable than passive approaches (based on sampling of indigenous species), as they implement reproducible strategies, control biotic confounding factors and provide robust, comparable
results.
If fishes are organisms of choice for checking compliance with biota EQSs, they have several characteristics that limit their use for active biomonitoring, while macroinvertebrates represent a good compromise in terms of feasibility and fulfilling the objectives of the WFD. (C) 2012 Elsevier Ltd. All rights reserved.”
“OBJECTIVE: To study whether pain location is related to lesion location in women with chronic pelvic pain and biopsy-proven endometriosis.
METHODS: A secondary analysis was performed to compare self-reported pain location with recorded laparoscopy findings for location and characteristics of all visible lesions. All lesions were excised. Endometriosis was diagnosed using histopathology criteria. The pelvic area was divided into three anterior and two posterior regions.