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“Idiopathic interstitial pneumonia frequently causes severe pulmonary restriction that in turn makes mechanical ventilation difficult. We report the case of a 44-year-old woman who developed a refractory severe hypercapnic respiratory failure (P-aCO2 281 mm Hg, pH 6.77) despite mechanical ventilation with high inspiratory pressure and PEEP. A pumpless extracorporeal lung assist device, Nova

lung, was used as rescue therapy for carbon dioxide removal, enabling lung-protective ventilation and normalization of life-threatening acidosis. Open lung biopsy revealed buy S3I-201 an idiopathic interstitial pneumonia with histological features of a nonspecific interstitial pneumonia. Corticosteroid therapy led to progressive improvement of pulmonary function, soon permitting cessation of mechanical ventilation and extracorporeal therapy. The patient was discharged from the intensive care unit after 20 days. This case demonstrates the successful use of pumpless extracorporeal lung assist as an alternative device to pump-driven extracorporeal membrane oxygenation in severe hypercapnic respiratory failure secondary,to nonspecific interstitial pneumonia.”
“Bean anthracnose caused by Colletotrichum lindemuthianum is one of the most destructive diseases in all bean growing areas. AFLP analysis was used to assess GANT61 mw genetic variability and relationships among C

lindemuthianum isolates from Slovenia. Isolates were obtained from different

common bean growing regions in Slovenia and have previously been characterized as races 23, 55, 103 and 131. Nutlin-3 cell line AFLP clustering revealed two main groups that did not clearly correspond to race classification based on pathogenicity towards differential common bean cultivars. Local common bean germplasm as well as the set of 12 international differential bean cultivars were evaluated for resistance against the four C. lindemuthianum races that occur in Slovenia. None of the 26 local common bean landraces and cultivars was resistant to all four races; however, six genotypes reacted as moderately resistant. Considerably higher level of resistance was recorded among differential common bean cultivars, particularly those derived from the Mesoamerican germplasm. Introgression of some major anthracnose resistance genes from the Mesoamerican germplasm is therefore recommended to develop resistant common bean cultivars for our production system.”
“Introduction: Heparin induced-thrombocytopenia (HIT) has been well recognized in Western countries. However, there are no data in the Thai population. We therefore investigated the prevalence of anti-platelet factor 4 (PF4)/heparin antibodies, HIT, and its thrombotic complications in Thai patients undergoing cardiac surgery using unfractionated heparin. Materials and methods: Seventy-three consecutive patients were prospectively enrolled in this study.