The authors thank Department of Clinical selleck products Biochemistry, Copenhagen University Hospital, Hvidovre (Copenhagen, Denmark) for quantifying IgG. The authors thank Anne-Louise Sørensen, Lotte Mikkelsen, and Lubna Ghanem (Copenhagen University Hospital, Hvidovre) for their general laboratory support as well as assistance locating samples and reagents, Jens Ole Nielsen and Ove Andersen (Copenhagen University Hospital, Hvidovre) for their support of the project, and Charles Rice (Rockerfeller University, New York, NY) and Takaji Wakita (National Institute of Infectious Diseases, Tokyo, Japan) for providing
reagents. Additional Supporting Information may be found in the online version of this article. “
“The traditional Chinese herbal medicine Sho-saiko-to is a mixture of seven herbal preparations that has long been used in the treatment of chronic liver disease. Various clinical trials
have shown that Sho-saiko-to protects against the development of hepatocellular carcinoma in cirrhotic patients. However, the mechanism by which Sho-saiko-to protects hepatocytes against hepatic fibrosis and carcinoma is not yet known. Basic science studies have demonstrated that Sho-saiko-to reduces hepatocyte necrosis and enhances liver function. Sho-saiko-to significantly inhibits hepatic fibrosis by inhibiting the activation of stellate cells, the major producers of collagen in the liver, as well as by inhibiting hepatic lipid peroxidation, promoting matrix degradation, and suppressing extracellular matrix BTK high throughput screening (ECM) accumulation. Furthermore, clinical trials have shown that
Sho-saiko-to lowers the rate of hepatocellular carcinoma (HCC) development in patients with cirrhosis and increases the survival of patients with HCC. Unfortunately, some case reports have shown the side selleck chemicals llc effects of Sho-saiko-to. Most of the side effects were interstitial pneumonia and acute respiratory failure induced by Sho-saiko-to in Japan. As a result of analyzing these case reports, the incidence and risk are increased by co-administration of interferon, duration of medication, and, high in an elderly population. This review discusses the properties of Sho-saiko-to with regards to the treatment of chronic liver diseases and suggests the side effects of Sho-saiko-to “
“The use of biological agents in inflammatory bowel diseases across the Asia-Pacific region is increasing. As new molecules and targets are identified, knowledge regarding the indications, utility, optimization and adverse effects of biological agents grows. Careful patient selection, attention to communication and patient education will maximize the benefit of these drugs. Tertiary referral centers with specific interest in inflammatory bowel diseases and experience play an important role in their use.