Conflict of interest statement None of the authors has any financial or personal relationships with people or organizations

that could inappropriately influence this work, although many members of the group have, at some stage in the past, received funding from a variety of pharmaceutical companies Alectinib solubility dmso for research, travel grants, speaking engagements or consultancy fees. Funding This work was funded by the Medical Research Council, UK (Grants G00001999 and G0600337). Development of the original version of the synthesis model was supported by Pfizer. The views expressed in this manuscript are those of the researchers and not necessarily those of the MRC. Chelsea and Westminster NHS Trust, Imperial College Healthcare NHS Trust, King’s College Hospital, the Mortimer Market Centre, the Royal Free NHS Trust, Barts and The London NHS Trust, Brighton and Sussex University Hospitals NHS Trust, Homerton University Hospital NHS Trust, The Lothian University Hospitals NHS Trust, North Bristol NHS Trust and North Middlesex University Hospital NHS Trust. Table S1. Observed and modelled estimates for time trends in HIV epidemiology in people aged >15 years in the United Kingdom in 2000–2007 Appendix S1. Supplementary Methods and Results Please note: Wiley-Blackwell

are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. “
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study was to compare the neuropsychiatric safety and tolerability of rilpivirine (TMC278) vs. efavirenz in a preplanned pooled analysis of data from the ECHO and THRIVE unless studies which compared the safety and efficacy of the two drugs in HIV-1 infected treatment naïve adults. ECHO and THRIVE were randomized, double-blind, double-dummy, 96-week, international, phase 3 trials comparing the efficacy, safety and tolerability of rilpivirine 25 mg vs. efavirenz 600 mg once daily in combination with two background nucleoside/tide reverse transcriptase inhibitors. Safety and tolerability analyses were conducted when all patients had received at least 48 weeks of treatment or discontinued earlier. Differences between treatments in the incidence of neurological and psychiatric adverse events (AEs) of interest were assessed in preplanned statistical analyses using Fisher’s exact test. At the time of the week 48 analysis, the cumulative incidences in the rilpivirine vs. efavirenz groups of any grade 2–4 treatment-related AEs and of discontinuation because of AEs were 16% vs. 31% (P < 0.0001) and 3% vs. 8% (P = 0.0005), respectively. The incidence of treatment-related neuropsychiatric AEs was 27% vs. 48%, respectively (P < 0.0001). The incidence of treatment-related neurological AEs of interest was 17% vs. 38% (P < 0.