PMv is also responsible for fingertip positions and elaborates the appropriate pattern of activation of intrinsic hand muscles (Davare et al., 2006). Positron emission tomography studies have shown abnormal activation patterns in the PMv and dorsal premotor cortex (PMd) in FHD (Ceballos-Baumann et al., 1997; Ibanez et al., 1999). These studies showed

a dysfunction of the premotor cortical network as well PLX4032 as a dysfunction of premotor cortex–basal ganglia circuits. Using transcranial magnetic stimulation (TMS), it has been demonstrated that the PMv has an inhibitory influence on the M1 at rest in healthy subjects (Davare et al., 2008). This PMv–M1 interaction is muscle specific and modulated GSK3 inhibitor during different phases of grasp preparation and execution (Davare et al., 2008). The aims of this study were to evaluate the PMv–M1 interactions during different phases of an index finger movement using a paired-pulse TMS paradigm, and to compare these interactions between patients with FHD and healthy volunteers. We hypothesized that the ipsilateral ventral premotor–motor inhibition would be involved in the physiology of SI and impaired in FHD. Eighteen patients with FHD (mean age 57.9 ± 6.4 years, 14 male) and 18 healthy volunteers

(mean age 55.7 ± 11.4 years, 11 male) participated in the study (see Table 1). Patients with FHD had unilateral, right hand, symptoms. One patient was left-handed but had symptoms in his right hand (musician’s dystonia, guitar player). Participants had no history of psychiatric disorders, neurosurgery or metal or electronic implants. Most patients had been treated with local injections of botulinum toxin type A in the affected hand and forearm muscles. For each patient, the last injection had been given at least 3 months prior to the recordings (Table 1). The study

was approved by the Institutional Review Board of the National Institute of Neurological Disorders and Stroke. All participants gave their Resveratrol informed oral and written consent before the experiments in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) and National Institute of Neurological Disorders and Stroke guidelines. Participants were seated in a comfortable armchair with both arms resting on a pillow placed on their laps. Their right hand was supported on a small board, to which a force transducer was attached (model S215 load cell; Strain Measurement Devices, Inc., Meriden, CT, USA). They rested their palm on the board, with the tip of their index finger on the force transducer. Electromyographic activity of the right first dorsal interosseus (FDI) and abductor pollicis brevis (APB) was recorded in a belly-tendon montage using Ag–AgCl surface electrodes. Impedances were kept below 5 kΩ.