Conclusion:  Fish oil induced the expression of cholesterol and bile acid transporters not only in liver but in intestine.

The upregulation of Abcg5/g8 by fish oil is caused by an increase in cellular 27-HOC through Cyp27a1 induction. The hepatic induction of bile acid synthesis through Cyp27a1 may upregulate expression of bile acid transporters in both organs. “
“Photodynamic therapy (PDT) can PI3K Inhibitor Library datasheet be used to treat a variety of gastrointestinal disorders. It uses the interaction of light and a type of drug called a photosensitizer to preferentially destroy lesions. This chapter discusses the application of PDT using several different photosensitizers and light delivery devices for the management of esophageal cancer, Barrett’s esophagus with high-grade dysplasia, cholangiocarcinoma, early stomach cancer, among other disorders of the gastrointestinal tract. “
“Systemic levels of interferon-gamma-inducible protein-10 (IP-10) are predictive of treatment-induced

clearance in chronic hepatitis C virus (HCV). In the present study, factors associated with plasma IP-10 levels at the time of acute HCV detection and the association between IP-10 levels and spontaneous clearance were assessed in three cohorts of acute DMXAA HCV infection. Among 299 individuals, 245 (181 male, 47 human immunodeficiency virus-positive [HIV+]) were HCV RNA+ at acute HCV detection. In adjusted analysis, factors independently associated with IP-10 levels ≥150 pg/mL (median level) included HCV RNA levels >6 log IU/mL, HIV coinfection and non-Aboriginal ethnicity. Among 245 Urease HCV RNA+ at acute HCV detection, 214 were untreated (n = 137) or had persistent infection (infection duration ≥26 weeks) at treatment initiation (n = 77). Spontaneous clearance occurred in 14% (29 of 214). Individuals without spontaneous clearance had significantly higher mean plasma IP-10 levels at the time of acute HCV detection than those with clearance (248 ± 32 versus 142 ± 22 pg/mL, P = 0.008). The

proportion of individuals with spontaneous clearance was 0% (0 of 22, P = 0.048) and 16% (27 of 165) and in those with and without plasma IP-10 levels ≥380 pg/mL. In adjusted analyses, favorable IL28B genotype was associated with spontaneous clearance, while higher HCV RNA level was independently associated with lower odds of spontaneous clearance. Conclusion: High IP-10 levels at acute HCV detection were associated with failure to spontaneously clear HCV. Patients with acute HCV and high baseline IP-10 levels, particularly >380 pg/mL, should be considered for early therapeutic intervention, and those with low levels should defer therapy for potential spontaneous clearance. (HEPATOLOGY 2013;) Spontaneous clearance of hepatitis C virus (HCV) occurs in 25% of individuals.

In conclusion, based on the performance demonstrated in this study, the Procleix HEV assay on the fully automated Panther System may be useful for both blood screening and diagnosis of HEV infection. Disclosures: Alanna Janssen – Employment: Hologic Lisa Danzig – Employment: Grifols Jeffrey M. Linnen – Employment: Hologic, Inc.; Stock Shareholder: Hologic, Inc. The following people have nothing to disclose: Edgar Ong, Robin Cory, Maria Babizki, Tim Shin, Andre Lindquist,

Ngoc-Anh Hoang, Lee P. Vang INTRODUCTION: There is limited data about the safety and effectiveness of sofosbuvir (SOF)-based therapies in “real-life” patients with HCV recurrence after liver transplantation (LT). AIM: To evaluate the safety and effectiveness of

SOF-based therapies in patients with HCV recurrence after LT. METHODS: This is a retrospective, multi-center study of patients with post-transplant HCV recurrence who received pegylated interferon (IFN) + ribavirin high throughput screening (RBV) + SOF (group 1) ; simeprevir (SMV) + SOF (group 2); SMV + SOF + RBV (group 3); or SOF + RBV (group 4). Treatment response by HCV RNA, cell counts, and adverse events (AE) were compared between groups. selleck inhibitor RESULTS: 59 patients (88% genotype 1a /1b, 51% F3/F4 fibrosis, 71% previously treated) were included in the analysis. Median time from transplant was 1297d (56-6209). There were no statistical differences in demographics, genotype, weight, fibrosis or laboratory parameters between the groups. Analysis of undetectable HCV RNA (UD) is shown in Table 1. Overall, 76% had generalized AE including fatigue, musculoskeletal complaints, headache and nausea, but the frequency of AE was similar between groups (p = 0.74). Serious AE including 1 death were reported in 14 patients (6 anemia/ mafosfamide cytopenia, 2 infection, 6 unrelated to therapy). Hgb decrease by >2 g and development of significant anemia (Hgb <10 g/ dL) was more frequent in patients receiving

RBV [85.7%(1), 10.5%(2), 80%(3), 73.1%(4) p=<0.0001] and [71.4%(1), 10.5%(2), 20%(3), 57.7%(4) p=0.003], respectively. Leukopenia and thrombocytopenia were more common in patients who received IFN. (p=<0.0001 and 0.002, respectively). The need for growth factors was higher in the IFN and RBV containing groups (p=0.005) and blood transfusions were more common in RBV containing groups (p=0.028). No changes in immuno-suppression doses were needed during treatment for any of the groups. SVR data will be presented. CONCLUSIONS: On treatment response using SOF based regimens in the treatment of HCV post-transplant appears promising. Treatment is well tolerated overall, but side effects are increased with RBV or IFN use. No immunosupression changes are needed when using SOF or SIM. Longer term data will help confirm safety and effectiveness in “real-life” patients. No significant difference between groups at week 2 and 4. Disclosures: Joseph Ahn – Advisory Committees or Review Panels: gilead; Grant/Research Support: bms Helen S.

Baseline demographics, endoscopic findings and histopathology were recorded and evaluated using Pearson’s chi-square. Results: Nineteen patients (15.8%) were categorized

as early-onset CRC while 101 patients (84.2%) were late-onset. The incidence of early-onset CRC was estimated at 1.2%; and late-onset CRC at 3.2%. No gender predilection this website was noted (p-value 0.184). Rectal bleeding was the most common chief complaint for both early-onset and late-onset colorectal cancer. Early-onset cancers were well-differentiated adenocarcinoma (52.6%) followed by mucinous adenocarcinoma (21.1%). Well-differentiated adenocarcinoma in the late-onset group was observed in 57.4% followed by high-grade dysplasia in the

background of adenoma (19.8%). There was a statistically significant difference in the histology in both groups (p-value 0.006). Conclusion: Early-onset cancers were predominantly well-differentiated adenocarcinoma followed by mucinous adenocarcinoma compared to late-onset cancers with well-differentiated adenocarcinoma followed by high-grade dysplasia. No significant difference was seen as to gender predilection, site of involvement and presence of synchronous lesions. Key Word(s): 1. colorectal cancer; Table 1. Characteristics of Early- and Late-Onset CRC Characteristic Early-Onset (n=18) Late-Onset (n=101) p-value N % N % Age, mean ± SD 44 ± 5.37   68 ± 10.9     Sex Female 11 55.5 44 43.6 0.184 Male 8 44.4 57 56.4 Location Cecum 0 0 8 7.9 0.371 Ascending MLN0128 clinical trial 0 0 11 10.9 Transverse 1 5.3 7 6.9 Descending 0 0 7 6.9 Sigmoid 6 31.6 21 20.8 Rectosigmoid 3 15.8 20 19.8 Rectal 9 47.4 27 26.7 Histopathology Adenocarcinoma Well-differentiated 10 52.6 58 57.4

0.006 Moderate 2 10.5 6 5.9   Poor 0 0 3 3.0   Intramucosal AdenoCa 1 5.3 12 11.9   Adenoma with dysplasia   0   0   High-grade 2 10.5 20 19.8   Low-grade 0 0 1 1.0   Mucinous AdenoCa 4 21.11 ASK1 1 1.0   Presence of polyps on multiple locations Yes 7 38.8 47 46.5 0.464 No 11 61.1 54 53.5   Two sites of cancer Yes 1 5.5 6 5.9 1.000 No 17 94.4 95 94.1 Presenting Author: RONA MARIEAGUILAR ATA Corresponding Author: RONA MARIEAGUILAR ATA Affiliations: Makati Objective: Current data on the prevalence of colorectal neoplasia in the country are lacking. The objectives of the present study are: to determine the prevalence of colorectal polyps and colorectal neoplasia among patients undergoing first-time colonoscopy; and to determine the distribution patterns and risk factors associated with colorectal neoplasia. Methods: A cross-sectional analysis of patients undergoing first-time colonoscopy was performed. Demographic, clinical, endoscopic and histopathologic data were recorded. Data analysis was done using frequencies and percentages Logistic regression analysis was used to determine the risk factors associated with the presence of colonic polyps.

In these patients four clinical features: (i) age at onset of the biliary symptoms; (ii) occurrence of acute complications, e.g., recurrent cholangitis or pancreatitis; (iii) occurrence of chronic complications, e.g., secondary sclerosing cholangitis, segmental MLN8237 datasheet dilatations of the intrahepatic biliary tract filled with gallstones; (iv) occurrence of ICP with or without severe complications (spontaneous premature delivery, fetal distress, stillborn fetus), were studied according

to the presence or not of ABCB4 variant, and the type of variation if present. All patients were identified by the clinicians responsible for their care. Informed consent was obtained from all subjects and the study was approved by the local Ethical Committee. Genomic DNA was obtained from peripheral white blood cells using standard procedures. To check selleck kinase inhibitor for the presence of sequence variants of the ABCB4 gene, 27 pairs of exon-specific primers were used to amplify the 27 coding exons of the ABCB4 gene together with their respective exon/intron boundaries. After purification, the polymerase chain reaction (PCR) products were sequenced using amplification

primers and the Big Dye Terminator Chemistry. Sequencing products were run after purification on an ABI 3130 Genetic Analyser (Applied Biosystems). Identification and localization of ABCB4 gene sequence variations were assessed by sequence comparisons with the SeqScape Software (v. 2.5; Applied Biosystems). Quantitative variables are expressed as means ± SD. Continuous variables were compared using the Wilcoxon rank sign test or the Kruskal-Wallis test when more than two groups were compared. Quantitative variables were compared using the chi-squared test. A difference was considered statistically significant when the P < 0.05. The R software was used

for all comparisons. A variant was detected in 79 (61 missense and 18 truncating sequence variants) of the 156 patients. The lists providing the sequence variations (nature, location, status) are provided in Tables 1 and 2. Among the 61 patients with missense variants, three were homozygotes and nine were compound heterozygotes. All the patients with a truncating variant were heterozygotes and four were compound heterozygotes. As shown in Table 3, age at onset of symptoms, sex ratio, frequency of either acute (cholangitis PTK6 or pancreatitis), or chronic complications (cholangitis with or without segmental dilatations of the intrahepatic biliary tree), ICP with or without fetal complications (spontaneous prematurity, fetal distress, stillborn fetus) did not differ significantly between the patients with or without ABCB4 variation. Overall, 70% of the patients with an altered genotype were women (P < 0.001); the mean age at the onset of symptoms was 38.7 years for men and 29.1 years for women (P < 0.003). Age at the onset of symptoms differed also according to the type of variant and gender.

53:71. S CLUGSTON,1 M RAVIKUMARA,2 D FORBES,2 G JEVON,3 C MEWS2 1Royal Perth Hospital, Perth, WA, 2Dept of Gastroenterology, Princess Margaret Hospital for Children, Perth, WA, 3Dept of Anatomic Pathology, Deforolimus research buy Princess Margaret Hospital for Children, Perth, WA Aim: To describe the clinicopathological characteristics in four children with collagenous gastritis. Methods: A review of the gastroenterology and histopathology data bases at Princess Margaret Hospital for Children,

identified four children diagnosed with collagenous gastritis in the last 10 years. Demographic details, clinical presentation, endoscopic and histological findings were extracted from the case notes. Results: The four children with collagenous gastritis were all female, age at diagnosis ranged from this website 8 to 15 years. Three of the children presented with iron deficiency, one of whom had previously been diagnosed with

coeliac disease. One patient presented with significant hematemesis. At endoscopy in three of the cases, there was hypertrophy of the gastric rugae with associated nodularity. The antrum was relatively spared. The one patient with coeliac disease had nodularity in the gastric fundus, however less hypertrophy of the gastric rugae. Gastric biopsies demonstrated significant sub epithelial collagen deposition in all cases. None had Helicobacter pylori identified. Conclusion: Collagenous gastritis is a rare condition in children however the diagnosis needs to be considered in children presenting with iron deficiency. Endoscopy and histopathology are required to

confirm the diagnosis. To our knowledge there are no previous reports of siblings with this condition. CH LEE,1,2 RW LEONG,3 E V O’LOUGHLIN,1 most KJ GASKIN1,2 1Department of Gastroenterology, the Children’s Hospital at Westmead, NSW, Australia, 2James Fairfax Institute of Paediatric Nutrition, the University of Sydney, NSW, Australia, 3Concord Repatriation General Hospital, NSW, Australia Introduction: Australia has among the highest incidence of inflammatory bowel disease (IBD) in the world. However, the incidence of pediatric IBD (PIBD) in New South Wales (NSW) has never been reported. We reviewed our experience in PIBD over 45 years at the Children’s Hospital at Westmead (CHW), the largest tertiary pediatric centre in NSW. Methods: Cases of PIBD from 1968 to 2013 were ascertained from lists kept prospectively by clinicians. Demographic and clinical details were extracted from the medical notes. NSW periodic census data were used for the catchment population denominator in the assessment of incidence. Based on published hospital activity data, we estimate that two thirds of the PIBD patients in NSW were managed at CHW. Results: 684 cases of PIBD (CD 404, UC 238, IBD-U 42) were managed in CHW during the study period. Age of diagnosis range from 6 weeks old to 17 years old (mean 10.68, median 11.33). 67% were older than 10 at diagnosis; 10% had very early onset IBD diagnosed before 5 years old.

Our data suggest that overweight or obese patients with NASH can successfully achieve a weight reduction of 7% to 10% of initial body weight and maintain it through 1 year of study participation. In the current study, participants in the lifestyle selleck kinase inhibitor intervention group lost an average of 9.3% from baseline weight as compared with 0.2% in the control group. Importantly, the results from this study suggest that lifestyle modifications focusing on diet, exercise, and behavioral changes can successfully

lead to improvements in overall NASH histological activity, degree of steatosis, and liver chemistry. Published studies on weight reduction as a treatment for NASH have several major limitations.30, 31 Most notably, there has yet to be a rigorously conducted randomized controlled trial to address the efficacy of weight reduction in adult patients with NASH. Most published studies have been either small retrospective or prospective case series without inclusion of a comparison group.32, 33 Many studies did not stratify patients according to histological criteria34 and thus may have included not only patients with NASH but also patients with simple steatosis who have a different natural history and clinical outcomes. In addition, these studies used primary outcomes that are not well accepted, such as serum aminotransferases

or sonographic findings.35–38 Another important shortcoming of earlier studies is that they used weight reduction strategies such as prolonged fasting39 or very-low-calorie AZD5363 dieting40 that cannot be sustained over a long period. Several recent pharmaceutical trials for NASH have included dietary intervention for comparison.8, 41 Although the effects www.selleck.co.jp/products/lonafarnib-sch66336.html of nutritional counseling in these studies appeared to be inferior to the investigational drugs, these dietary interventions produced minimal or no weight loss and thus cannot address the question of whether weight loss leads to improvements in NASH. This study had a number of strengths, including

the selection of patients with well-characterized NASH both clinically and histologically, the randomized design, the high completion rate (97%, only one dropout), and the use of the current histological scoring criteria by NASH Clinical Research Network. In addition, our study used a standardized, protocol-based lifestyle intervention similar to the programs implemented in the Diabetes Prevention Program15 and Look AHEAD, an ongoing study with overweight individuals with type 2 diabetes.18 The effect sizes for overall NASH disease activity (Cohen’s d = .82) and steatosis (Cohen’s d = .97) were large, and thus differences between lifestyle and control were statistically significant even with the relatively small sample size.

Physiological processes, such as secretion, digestion,

absorption, and motility, occur in response to these luminal substances, implying the presence of mucosal chemosensors, which evoke protective mucosal defense mechanisms.1 The duodenal mucosa rapidly responds to luminal chemical stimuli, not only by enhancing local defense factors, such as mucosal blood flow and HCO3- and mucus secretion, but also by inhibiting gastric emptying and secretion, in addition to producing symptoms, such as bloating, nausea, and fullness. Gastric inhibition in response to duodenal luminal substances is termed “duodenal feedback” or “duodenal brake”, originally described by Andersson in 1960.2 Intraduodenal acid inhibits gastric acid secretion and delays gastric emptying via neuronal reflexes and the release of gastric inhibitory peptide/glucose-dependent insulinotropic BTK pathway inhibitors peptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, cholecystokinin (CCK),

secretin, and somatostatin. Our laboratory has provided data supporting the hypothesis that luminal acid is sensed via submucosal cation channels expressed on afferent nerves. Luminal acid is converted to this website CO2 at the surface of the epithelial cells through mixture with secreted HCO3- and membrane-bound carbonic anhydrase activity.3 CO2 enters the cell and is hydrated to HCO3- and H+ by cytosolic carbonic anhydrase, with the H+ exiting across the basolateral membrane via the Na+/H+ exchanger NHE1, with HCO3- secreted across the apical cell membrane.4 In this fashion, large quantities of gastric acid are absorbed as the non-toxic acid equivalent CO2, which will not injure the epithelial cells. As a consequence, luminal acid is rapidly sensed by submucosal chemosensors, such as transient receptor potential vanilloid-1, which transduce the luminal chemical signal into neural

Ureohydrolase afferent responses and can then trigger efferent neurohormonal responses.5 Disruption or dysregulation of these duodenal physiological responses to postprandial luminal acid could be related to the pathogenesis of mucosal injury and nociception. Functional dyspepsia (FD) is a heterogeneous symptom complex including upper abdominal discomfort or pain, postprandial fullness, early satiety, nausea, vomiting, and bloating in the absence of organic disease, as defined by the Rome III criteria.6 Although the pathogenesis of FD is unknown, dysmotility, gastric relaxation disorders, or sensory disorders have been hypothesized. Recently, FD symptoms were correlated with duodenal acidity in basic and clinical studies.7 Although proton pump inhibitors relieve dyspepsia, gastric acid secretion or gastric mucosal acid sensitivity is normal in most FD patients.

Alteration of intestinal permeability and tight junction (TJ) is considered a key player due to development of PI-IBS. The aim of this study was to determine whether probiotics could normalize the intestinal epithelial barrier and expression of

TJ proteins such as occludin, claudin-1 and zonula occludens-1 (ZO-1). Methods: Visceral hypersensitivity was induced by Trichinella spiralis infection in mice. At 8 weeks post infection (PI), mouse were gavaged daily for 7 days Temozolomide molecular weight with different strains of probitics respectively (Befidobacterium longum, Lactobacillus acidophilus, Streptococcus faecalis or mixture of the three). Plasma levels of diamine oxidase (DAO) and d-lactate were determined using an enzymatic spectrophotometry. Expression of occludin, claudin-1 and ZO-1 in ileum was determined by Western blotting. Results: 1) Plasma DAO level significantly

increased in PI-IBS group (14.25 ± 2.49 U/ml) compared with control group (8.80 ± 1.64 U/ml, p < 0.05). After administration of Bif.longum, Lac.acidophilus and mixture, plasma DAO levels were decreased Bioactive Compound Library concentration obviously while there is no change in group of Strep.faecalis; 2) Similarly, plasma d-lactate were reduced in groups of Bif.longum, Lac.acidophilus and mixture but group of Strep.faecalis has no reduction; 3) in ileum, claudin-1 in PI-IBS (0.87 ± 0.24) was lower than that of control group (1.21 ± 0.26, p < 0.05). No difference was observed in occludin and ZO-1 between control group and PI-IBS group. In the comparison of PI-IBS, claudin-1 of groups of Bif.longum, Lac.acidophilus and mixture were significantly increased in ileum. Farnesyltransferase Interestingly, expression of claudin-1 of group of mixture was higher than control but other groups were not.; 4) There were significant negative correlations between claudin-1 and DAO (r2 = 0.875, P < 0.05). Conclusion: Befidobacterium longum and Lactobacillus acidophilus but not Streptococcus faecalis, can improve the intestinal permeability of PI-IBS. The mixture

of the three is the most effective. The close correlation between expression of tight junction and plasma levels of DAO supports the hypothesis that probiotics normalize intestinal permeability after infection because of increase in the expression of TJ proteins. Key Word(s): 1. PI-IBS; 2. Probiotics; 3. TJ protein; Presenting Author: LEIJIA LI Additional Authors: JIN TAO, SHENGLIANG CHEN Corresponding Author: LEIJIA LI Affiliations: The Third Affiliated Hospital of Sun Yat-Sen University; Renji hospital, Shanghai Jiaotong university, school of medicine Objective: To construct the lentiviral vector encoding alkB gene and investigate its effect on proliferation and activity of human gastric cancer cells.

Aims: The aim of this study was to investigate duration of IFX infusions, use of premedication and in centres who had changed infusion duration whether there was an increase in side-effects

or loss of clinical response. We also assessed whether routine measurement of anti-infliximab antibodies (ATIs) or IFX trough (IFXT) levels were being used to guide treatment. Methods: We performed a telephone survey during the period March to May 2013. We included all major public hospitals within Australia where children with CD were regularly being treated with IFX. The paediatric gastroenterology (PG) fellow/registrar or PG nurse specialist was contacted. Results: The response rate was 88% (N = 8). Across Australia there is significant variation in infusion duration. The median infusion time in units studied was 2 hours (range 1.5 hours- 4 hours). All centres either regularly or always used premedication with corticosteroids. The single buy PD0332991 centre using 90 minute infusions did not report an increase in side effects or loss of clinical response. No unit was routinely using ATIs or IFXT levels to guide dosage. Conclusion: Wide variation exists in the practice of IFX administration in paediatric CD. The impact these variations have

on outcomes is uncertain. Ideally before changing to the more rapid ‘adult style’ Midostaurin ic50 protocol, a prospective study should be undertaken to assess safety, efficacy and the role of specific biochemical monitoring. G SEIBOTH, D MOORE, R COUPER, P HAMMOND, S BARRY, S KRITAS Gastroenterology Unit, Women’s & Children’s Hospital, WCHN, North Adelaide SA, Australia Introduction: Gastroesophageal reflux (GOR) is a very common condition in children. Currently the standard test for measuring reflux is the 24 h pH probe. A number of studies have investigated the advantage of adding impedance versus pH alone for symptom association however the advantage

for diagnostic yield of reflux without symptom association is yet to be established. The aim of this study was to investigate the diagnostic yield of adding impedance to 24 h pH testing for GOR. Methods: A retrospective analysis of 24 h Dolutegravir datasheet pH/impedance studies completed at the Women’s and Children’s Hospital between 2008 and May 2013 was performed. Studies were categorised according to the following criteria: negative or positive for pH only if total reflux index was >5%, negative or positive for impedance only if total number of episodes >75, negative or positive for both. Results: One hundred and twenty three 24 h pH/impedance studies were included (mean age 4.4 ± 0.5 years, 44% male). Sixty five studies were negative for GOR both by pH only and pH/impedance analysis. Twenty studies were positive for pH only and 16 studies were positive for both pH and impedance. Twenty two studies were found positive for only impedance increasing the diagnostic yield from 41% to 89% (p = 0.006).

In group A (n = 25), BC performed following SC detected 15 additional MI-503 chemical structure polyps, resulted in 107%

additional detection rate. In group B (n = 24) SC performed following BC detected 1 additional polyp, resulted in 11% additional detection rate. Additional detection rate ratio, which represents the probability of missing a polyp during the first procedure with SC compared to the first procedure with BC is 107/11 = 9.72. This ratio is compared to published additional detection rate ratios of 2.56 (PDR) and 1.86 (ADR) in the Third Eye Retroscope and Cap fitted Colonoscopy tandem studies, respectively. Conclusion: BC using the balloon-colonoscope and withdrawal technique is safe, easy to use and demonstrates substantial increase in PDR during colonoscopy. Key Word(s): 1. CRC; 2. Balloon Colonoscope; 3. Polyp Detection; 4. Colonoscopy; Presenting Author: YINXUN HAI Corresponding Author: YINXUN HAI Affiliations: The First Affiliated Hospital of

Harbin Medical STA-9090 concentration University Objective: To discuss the difference between of Sodium Phosphates Oral Solution and Polyethylene Glycol-Electrolyte Powder in intestinal cleaning before colonoscopy. Methods: 107 patients was divided into 2 groups at ramdom, and Analysis the difference after they take Sodium Phosphates Oral Solution (Group A) and Polyethylene Glycol-Electrolyte Powder (Group B) seperatedly. RESULTS: The effective rate of group A and B was 75.68% and 77.14% respectively,

and the amount of residual feces was close. Results: The selleck products effective rate of group A and B was 75.68% and 77.14% respectively, and the amount of residual feces was close. Conclusion: There was no significant difference between two grouops in intestinal cleaning. The application scheme of one bottle of Sodium Phosphates Oral Solution should be promoted clinically. Key Word(s): 1. Intestinal cleaning; 2. Oral Solution; Presenting Author: LULI FENG Corresponding Author: LULI FENG Affiliations: beijing friendship hospital Objective: The success rate of repeat endoscopic retrograde cholangiopancreatography (ERCP) after a failed initial attempt is unknown. Our aim was to determine the success rate of repeat ERCP with a failed ERCP procedure. Methods: A review of 168 repeat ERCP procedures was performed at Beijing Frend Hospital affiliated to the Capital medical university in the year2003–2013. Results: 168 endoscopy was repeated after unsuccessful procedures, and access to the desired duct was achieved in 90%(151/168) of repeat attempts. No complications occurred with repeat ERCP. Of the 17 patients who underwent failed repeated ERCP, 6 was not available for the follow-up study, 6 had metastatic cancer, and the other had pancreas divisum. Conclusion: Repeat ERCP yields an 90% success rate. This leads to an overall success rate of 91.0% Key Word(s): 1. ERCP; 2. canulation; 3. endoscopy; 4.