A centerpiece in the defense against oxidative stress is the Nrf2 (nuclear factor (erythroid-derived-2)-like 2)-mediated transcriptional upregulation of antioxidant and detoxifying enzymes and the removal of oxidatively damaged material. Autophagy has an important role in the intracellular degradation of damaged proteins Dibutyryl-cAMP supplier and entire organelles, but its role in the epidermis has remained elusive. Here, we show that both

UVA and UVA-oxidized phospholipids induced autophagy in epidermal keratinocytes. Oxidative stressors induced massive accumulation of high-molecular-weight protein aggregates containing the autophagy adaptor protein p62/SQSTM1 in autophagy-deficient (autophagy-related 7 (ATG7) negative) keratinocytes. Strikingly, even in the absence of exogenous stress, the expression of Nrf2-dependent genes was elevated in autophagy-deficient keratinocytes. Furthermore, we show that autophagy-deficient cells contained significantly elevated levels of reactive oxidized phospholipids. Thus, our data demonstrate that autophagy is crucial for both the degradation of proteins and lipids modified by environmental UV stress and for limiting Nrf2 activity in keratinocytes. Lipids that GSK1120212 in vitro promote inflammation and tissue damage because of their reactivity and signaling functions are commonly observed in aged and diseased skin, and thus targeting

autophagy may be a promising strategy to counteract the damage promoted by excessive lipid oxidation.”
“The association of persistent presence of circulating antiphospholipid antibodies and thromboembolic events, (recurrent) pregnancy loss or both is termed antiphospholipid syndrome. Pregnancies

in women with the syndrome should be regarded P005091 inhibitor as at high-risk for complications. Optimal management consisting of close follow-up and pharmacological treatment can result in about 70-80% live births. Apart from the laboratory diagnosis of the syndrome and pathophysiology, this review will focus on treatment during pregnancy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.”
“Chronic rhinosinusitis (CRS) is one of the most common inflammatory diseases with affecting large number of patients globally. The pathogenesis of CRS is still unclear and the treatment is unsatisfied. Clinical data provide the evidence that the chilblain-like alteration occurs in the early pathophysiology of CRS. We hypothesize that thermotherapy may offer a novel possible treatment strategy of chronic rhinosinusitis. In this article, we discuss the possibility of the chilblain-like alteration in the early pathophysiology and a therapeutic role of thermotherapy. (C) 2011 Elsevier Ltd. All rights reserved.”
“Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity.

Such a scenario could explain how spreading and migration are oriented by the rigidity of the cell environment.”
“Some aspects of the functional, morphological, and morphometrical characteristics of chronic progressive nephropathy occurring in 18- to 26-month-old male rats and in 3-month-old control rats were studied. Rats with chronic progressive nephropathy were proteinuric and showed a slight increase in serum creatinine

and no changes in blood pressure. The morphological changes were studied by light microscopy, high-resolution light microscopy, and electron microscopy. They showed focal and segmental or global glomerulosclerosis, the Tyrosine Kinase Inhibitor Library three types of atrophic tubules (“classic,” “thyroid-like,” and “endocrine”) described by Nadasdy et al, as well as interstitial fibrosis with mononuclear cell infiltrates. On certain occasions, small vessels showed hyalinosis. Glomerular morphometrical studies showed a biphasic pattern in the glomeruli progressing toward obsolescence. Vascular morphometrical studies showed significant increase in media wall thickness and media cross-sectional area in

the 18- to 26-month-old signaling pathway rats. These results support the hypothesis that changes in the vascular system are not of utmost importance in the pathogenesis of chronic progressive nephropathy, and that glomerular sequential changes seem to be of paramount significance in the progression of the disease.”
“Sarcomas are frequent tumors in children and young adults that, despite a relative chemosensitivity, show high relapse rates with up to 80% of metastatic patients

dying in 5 years from diagnosis. The real ontogeny of sarcomas is still debated and evidences suggest they may derive from precursors identified within mesenchymal stromal/stem cells (MSC) fractions. Recent studies on sarcoma microenvironment additionally GDC-0994 indicated that MSC could take active part in generation of a supportive stroma. Based on this knowledge, we conceived to use modified MSC to deliver tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) targeting different sarcoma histotypes. Gene modified MSC expressing TRAIL were cocultured with different osteosarcoma, rhabdomyosarcoma, and Ewing’s Sarcoma (ES) cell lines assessing viability and caspase-8 activation. An in vivo model focused on ES was then implemented considering the impact of MSCTRAIL on tumor size, apoptosis, and angiogenesis. MSC expressing TRAIL induced significantly high apoptosis in all tested lines. Sarcoma death was specifically associated with caspase-8 activation starting from 8 hours of coculture with MSC-TRAIL. When injected into pre-established ES xenotransplants, MSC-TRAIL persisted within its stroma, causing significant tumor apoptosis versus control groups. Additional histological and in vitro studies reveal that MSC-TRAIL could also exert potent antiangiogenic functions.

This rare auto-inflammatory disease is classically described by the “Still’s triad” of fever, rash, and arthritis, although the atypical cases frequently outnumber the typical ones. The exact pathogenesis and etiologic factors responsible for the clinical features remain largely obscure, despite recent suggestive cytokine biology findings. Diagnosis is made on clinical grounds, following the exclusion of mimickers

of infectious, autoimmune or neoplastic etiology, with the additional consideration of non-specific Fosbretabulin solubility dmso laboratory abnormalities such as peripheral leukocytosis and elevation of serum ferritin and other acute phase reactants. The disease manifestations are protean and can include diverse complications, affecting multiple organ systems. Moreover, the severity of the organ involvement can vary considerably, representing a wide spectrum from the self-limited to severe. The mainstay of therapy has evolved

from the traditional use of corticosteroids and oral immunosupressants to the newer targeted treatments with biologic drug discovery agents. The scope of this review is to alert the clinician to the existence of life-threatening AOSD complications, namely the macrophage activation syndrome, disseminated intravascular coagulopathy, thrombotic thrombocytopenic purpura, diffuse alveolar hemorrhage, and pulmonary arterial hypertension. Such knowledge may lead in earlier recognition, prompt treatment, and, ideally, improved patient outcomes.”
“Continuously growing rodent incisors have a special epithelial structure for maintaining adult stem cells that shows a bulbous epithelial protrusion at the apical end and is referred to as an “apical bud”. Guinea pig cheek teeth (premolars and molars), also continuously growing teeth, have a complex crown shape consisting of plural cusps. The present study clarifies the existence of apical buds in guinea pig premolars/molars buy AZD7762 as it examines the relationship between the crown shape and the orientation of the apical buds by micro-computed tomography (mu-CT) and immunohistochemistry for 5-bromo-2′-deoxyuridine

(BrdU). One premolar and three molar teeth in each side of the maxillae and mandibles assumed characteristic features: each horizontally-sectioned tooth showing a complex zigzag shape was composed of a core of dentin covered by a layer of enamel on all axial surfaces except the buccal of the uppers and the lingual of the lowers. Furthermore, four bulbous epithelial protrusions-including the stellate reticulum were recognized in the apical end of each tooth, where slow-cycling long-term label-retaining cells resided 20 days after a peritoneal injection of BrdU. These data indicate that guinea pig premolars/molars have four apical buds where the epithelial adult stem cells reside. In contrast, rodent incisors, which show a single cone appearance, are covered by enamel on the labial side and possess only one apical bud.

(c) 2013 Elsevier Inc. All rights reserved.”
“Purpose. To review the newer treatments for bacterial keratitis. Data Sources. PubMed literature search up to April 2012. Study Selection. Key words used for literature search: “infectious keratitis”, “microbial keratitis”, “infective keratitis”, “new treatments for infectious keratitis”, “fourth generation fluoroquinolones”, “moxifloxacin”, “gatifloxacin”, “collagen cross-linking”, and “photodynamic therapy”. Data Extraction. Over 2400 articles were retrieved. Large scale studies or publications at more recent dates were selected. Data Synthesis. Broad spectrum antibiotics have been the main stay of treatment

for bacterial keratitis but with the emergence of bacterial resistance; there is a need for newer antimicrobial agents and treatment methods. Fourth-generation fluoroquinolones and corneal collagen cross-linking are amongst the new treatments. In vitro studies and prospective Selleckchem Tariquidar clinical trials have shown that fourth-generation fluoroquinolones are better than the older generation fluoroquinolones and are as potent as combined fortified antibiotics against common pathogens that cause bacterial keratitis. Collagen cross-linking was shown to improve healing of infectious corneal ulcer in treatment-resistant cases or as an adjunct to antibiotics treatment. Conclusion. Fourth-generation fluoroquinolones

are good alternatives to standard treatment of bacterial keratitis

using combined fortified topical antibiotics. Collagen cross-linking may be considered in treatment-resistant infectious keratitis or as an adjunct to antibiotics therapy.”
“Land CCI-779 managers are routinely applying fuel reduction treatments to mitigate the risk of severe, stand-replacing fire in ponderosa pine communities of the southwestern US. When these treatments are burned by wildfire they generally reduce fire severity, but less is known about how they influence post-wildfire vegetation recovery, as compared to pre-fire untreated areas. We re-measured existing plots on the 2002 Rodeo-Chediski Fire 8 years after the wildfire to track plant community and exotic species response, as well as patterns Fludarabine molecular weight of pine regeneration. We compared areas that experienced high- and low-severity burning, and also examined how pre-fire treatment (cutting in an uneven-aged harvesting system with prescribed fire) modified vegetation response. We detected persistent differences between low- and high-severity areas for nearly all variables measured. In high-severity areas overall understory plant cover was 40.6%, nearly three times that observed in low-severity areas; shrub cover was 18.4%, four and a half times greater than that observed in low-severity areas. We also detected significantly higher exotic forb cover in high-severity areas, although overall exotic response was generally quite low (<2%).

(C) 2009 Elsevier B.V. All rights reserved.”
“Eighteen Girgentana lactating goats, nine homozygous for strong alleles (AA) and nine homozygous for weak alleles (FF) at alpha(s1)-casein (CSN1S1) locus, were used to evaluate the effect of genotype, diet and genotype x diet (G x D) interaction on the composition NSC23766 in vitro of goat milk caseins. Goats were used in a 2 x 2 factorial arrangement of treatments, with two genotypes (AA, FF) and two diets at different energy levels (high-energy diet (D65) and low-energy diet (D100)). The experiment consisted of two simultaneous 2 x 2 Latin squares for the two genotypes, with one square for each level of energy. Capillary electrophoresis was used for the determination of relative

casein (CN) composition. alpha(s1)-CN, kappa-CN and beta-CN yield was significantly higher with 065 than D100 (10.2 vs 7.2; 3.8 vs 2.6; 18.6 vs 13.6 g/d, respectively). Genotype significantly affected (P < 0.05) alpha(s2)-CN and alpha(s1)-CN yield: alpha(s1)-CN was higher in AA than FF goat milk (15.5 vs 2.4 g/d). while alpha(s2)-CN was higher in FF than M goat milk (4.7 vs 2.8 g/d); no genotype effect (P > 0.05) was reported for kappa-CN and beta-CN yield. As concerning individual casein concentration, alpha(s1)-CN was higher for AA than FF goat (12.4 vs 1.5 g/kg milk), whereas alpha(s2)-CN and beta-CN were higher in FF than AA milk (4.3 vs 1.4; 15.6 vs 12.9 g/kg, respectively); also kappa-CN tended to be higher in FF goats. Diet

did not significantly influence

concentration of individual caseins. A significant G x D interaction AZD8931 cost was found only for alpha(s1)-CN concentration, which decreased (-10%) when AA goats shifted from D100 to D65. In conclusion, high energy input consistently improved total casein yield beside genotype. The higher casein yield of AA goats mainly depends on ctsiCN biosynthesis; moreover, the lower presence of alpha(s1)-CN in FF goat milk may be partially counterbalanced by the other caseins. (C) 2011 Elsevier B.V. All rights reserved.”
“Background: Sickle cell disease (SCD) is a chronic, incurable hereditary disease. The vaso-occlusive crisis (VOC) is the most frequently occurring acute complication in sickle cell Ricolinostat patients and accounts for the majority of SCD-related hospital admissions. Another major complication is the potentially fatal acute chest syndrome (ACS). The prototypic long pentraxin-3 (PTX3), an acute phase protein and a key component of innate immunity, is linked to ischemia-induced inflammation, a condition incriminated in SCD complications. Aim: To investigate the expression of PTX3 in stable SCD and VOC patients and to assess its relation to the development and progression of ACS. Subjects and methods: We conducted this study on 160 patients with confirmed SCD (20 stable SCD and 140 in VOC), and 10 healthy age-and sex-matched controls. Patients were diagnosed as SCD by high-performance liquid chromatography. PTX3 levels were assessed using enzyme-linked immunosorbant assay.

\n\nConclusion: [111-In] pentetreotide SPECT/CT imaging at

24 hours identifies pathologic disease sites and distinguishes physiologic activity equally well compared to traditional strategies using 2 imaging days. Routine use of SPECT/CT will allow single time-point imaging without loss of diagnostic accuracy, enhancing patient convenience, and clinical throughput.”
“Background: Percutaneous nephrolithotomy (PCNL) can be performed in the prone or in the supine position. Comparisons between the two techniques in obese patients are rare in the current literature.\n\nMethods: The records of obese patients (body mass index >30) who underwent PCNL in the prone or complete supine positions were reviewed. All patients had a noncontrast CT before and after the procedure. Stones were graded according to the Guy stone

score and complications according to the Clavien www.selleckchem.com/products/azd4547.html grading. The stone-free rates, operative time, surgical complications, and hospital stay were analyzed.\n\nResults: A total of 56 PCNL were performed in 42 patients. Twenty-four PCNL were performed in the prone and 32 in the total supine position. Stone-free rate on the first postoperative day was 50% in the prone and 46.9% in the supine SB202190 ic50 position (P = 1.0). Final stone-free rates were 83.3% and 78.1%, respectively (P = 0.74). Mean operative time was 164.6 minutes in the prone and 120.3 minutes in the supine position (P = 0.0017), and hospital stay was 4.38 and 2.68 days (P = 0.014), respectively. The transfusion rate was 20.8% in the prone and zero in the supine position patients (P = 0.01).

Excluding Guy IV stones, transfusion rate was 8.3% in the prone position (P = 0.1). Significant surgical complications rate was 12.5% in the prone and 3.1% in the supine position (P = 0.302).\n\nConclusion: PCNL performed in the prone or in the complete supine position in obese patients presents similar outcomes. The supine decubitus position has the advantages of a significantly shorter operative time and hospital Emricasan price stay.”
“Objective: To assess the efficacy of upper airway surgical intervention in patients with Prader-Willi syndrome (PWS). Due to reports of sudden death in children undergoing treatment with growth hormone for PWS, detection of sleep-disordered breathing by polysomnography (PSG) has been recommended.\n\nDesign: Retrospective study.\n\nSetting: Multidisciplinary PWS Center at a tertiary care children’s hospital.\n\nPatients: Thirteen pediatric patients with PWS who underwent adenotonsillectomy (T&A) with pre-PSG and post-PSG.\n\nMain Outcome Measures: Comparison of PSG results before and after T&A.\n\nResults: Six of our patients were girls (46%); 8 had genetic characteristics consistent with deletion (61%), and the remaining 5 had genetic characteristics consistent with uniparental disomy (39%). The median age at T&A was 3 years (age range, 6 months to 11 years), and the median age at start of growth hormone treatment was 8.5 months (range, 2 months to 6 years).

The aim of this study was to investigate the effects of soy phytoestrogens and the natural estrogen 17 beta-estradiol (E-2) to determine whether one of the estrogen receptors is mobilized for the action of these compounds on DNA methylation. We also made a comparative study with a DNA methylation inhibitor (5-azacytidine)

see more and a DNA methylation activator (budesonide). Three prostate cell lines, PC-3, DU-145, and LNCaP, were treated with 40 mu M genistein, 110 mu M daidzein, 2 mu M budesonide, 2 mu M 5-azacytidine, and 10 mu M E-2. In these 3 human prostate cancer cell lines, we performed methylation quantification using methyl-profiler-DNA-methylation analysis. Soy phytoestrogens and E-2 induced a demethylation of all the promoter regions find more studied except for those that were unmethylated in control cells. Our results showed that E-2 induces, like soy phytoestrogen, a decrease in DNA methylation in prostate cancer cell lines. This action may be mediated through ER beta.”
“BackgroundMelanoma accounts for a small proportion of skin cancers

but is the most serious. The prognosis is, however, good if it is diagnosed early, before the metastatic stages. For these reasons, population awareness and knowledge with regard to melanoma and the associated risk factors are critical to improving the effectiveness of melanoma primary prevention campaigns. ObjectivesThe EDIFICE Melanoma survey was designed to cover a large number of topics related to sun exposure and melanoma: knowledge and awareness of the risks associated with sun and artificial ultraviolet exposure, knowledge of melanoma and the associated risk factors, behaviour regarding protective measures in adults and children. MethodsThe survey questionnaire was administered by experienced independent interviewers from the Kantar Health Institute using the Computer-Assisted Telephone Interview technique. It was important to avoid the effects of contamination’ in answers to questions about sun exposure habits. Questions about exposure habits were

therefore asked before those relating to knowledge of best practices for sun protection. A sample of 1502 individuals aged 18years click here and over was interviewed. The survey data were weighted to eliminate structural variations between the sample interviewed and the reference population. Quantitative data were described by the means and standard deviations and categorical data by the numbers in each category and corresponding percentages. Three multivariate logistic regression analyses were conducted and expressed in terms of odds ratio and 95% confidence intervals. ResultsIn addition to the classic questions relating to sociodemographic characteristics, the EDIFICE Melanoma study questionnaire was organized around three themes: the opinion, attitude and knowledge of individuals regarding sun exposure and melanoma. The survey questionnaire lasted approximately 20min.

The comparison of the proposed methodology to comparative molecular field analysis (CoMFA) formalism was performed. This methodology explores jointly the main features Selleck Alisertib of CoMFA and 4D-QSAR models. Step-wise multiple linear regression was used for the selection

of the most informative variables. After variable selection, multiple linear regression (MLR) and partial least squares (PLS) methods used for building the regression models. Leave-N-out cross-validation (LNO), and Y-randomization were performed in order to confirm the robustness of the model in addition to analysis of the independent test set. Best models provided the following statistics : R-2 = 0.943, q(LOO)(2) = 0.802, q(LNO)(2) = 0.798, R-Pred(2) = 0.936 (PLS) and R-2 = 0.948, q(LOO)(2) = 0.823, q(LNO)(2) = 0.818, R-Pred(2) = 0.928 (MLR). Docking study was applied to investigate the major A-1331852 research buy interactions in protein-ligand complex with CDOCKER algorithm. Visualization of the descriptors of the best model helps us to interpret the model from the chemical point of view, supporting the applicability of

this new approach in rational drug design.”
“Objective. To assess maternal and perinatal morbidity in patients undergoing a trial of labor after cesarean section (TOLAC) in twin gestations.\n\nMethods. A retrospective study including all twin pregnancies with a single prior cesarean section was performed. Stratified analysis using a multiple logistic regression model was performed to control for confounders. Patients who had a clear medical indication for a cesarean section (i.e. previous corporeal cesarean section, breech or transverse presentation, placenta previa, placental abruption, and herpes infection) were excluded from the analysis.\n\nResults. During the years 1988-2007, 134 patients met the inclusion criteria. Of these, 25 patients underwent a trial of labor and the remaining 109 underwent a repeat cesarean LBH589 in vitro delivery. There were no cases

of uterine rupture, maternal mortality, or peripartum fever in our population. Higher rates of perinatal mortality were noted in patients undergoing a trial of labor (8% vs. 1.8%, p = 0.042, OR = 4.652, 95% CI = 1.122-19.286). However, a trial of labor was not found to be an independent risk factor for perinatal mortality after controlling for confounders such as gestational age, ethnicity, and fetal malformations (adjusted OR = 1.07, 95% CI = 0.07-15.95, p = 0.95).\n\nConclusions. A TOLAC is not associated with an increased risk for maternal morbidity, including uterine rupture. Nevertheless, in our population TOLAC was noted as a risk factor for perinatal mortality, although residual confounding cannot be excluded. Further prospective randomized studies should evaluate the safety of TOLAC in twin gestations to establish appropriate guidelines.

In conclusion, animal models of diabetes type 1 and diabetes type 2 could be used in pharmacological studies, where cutaneous changes could be used as outcome measures for predegenerative markers of neuropathies. (C) 2013 Elsevier B.V. All rights reserved.”
“Background- Organizational and wider health system factors influence the implementation and success of interventions. Clinical MDV3100 Pathways in Acute Coronary Syndromes 2 is a cluster randomized trial of a clinical pathway-based intervention to improve acute coronary syndrome care in hospitals in China. We performed a qualitative evaluation to examine the system-level barriers to implementing

clinical pathways in the dynamic healthcare environment of China. Methods and Results- A qualitative descriptive analysis of 40 in-depth interviews with health professionals conducted in a sample of 10 hospitals purposively selected to explore barriers to implementation of the intervention. Qualitative data were analyzed using the Framework

method. In-depth interviews identified 5 key system-level barriers to effective implementation: (1) leadership support for implementing quality improvement, (2) variation in the capacity of clinical services and quality improvement resources, (3) fears of patient disputes and litigation, (4) healthcare funding constraints and high out-of-pocket expenses, and (5) patient-related factors. Conclusions- System-level barriers affect the ability of acute coronary syndrome clinical pathways to change practice. Addressing these barriers in the context Selleck Epigenetic inhibitor of current and planned national health system reform will be critical for future improvements in the management of acute coronary syndromes, and potentially other hospitalized conditions, in China. Clinical Trial Registration- MS-275 cell line URL: http://www.anzctr.org.au/default.aspx.

Register. Unique identifier: ACTRN12609000491268.”
“G protein-coupled receptors are involved in the modulation of complex neuronal networks in the brain. To investigate the impact of a cell-specific G(i/o) protein-mediated signaling pathway on brain function, we created a new optogenetic mouse model in which the G(i/o) protein-coupled receptor vertebrate rhodopsin can be cell-specifically expressed with the aid of Cre recombinase. Here we use this mouse model to study the functional impact of G(i/o) modulation in cerebellar Purkinje cells (PCs). We show that in vivo light activation of vertebrate rhodopsin specifically expressed in PCs reduces simple spike firing that is comparable with the reduction in firing observed for the activation of cerebellar G(i/o)-coupled GABA(B) receptors. Notably, the light exposure of the cerebellar vermis in freely moving mice changes the motor behavior.

Normal latent inhibition was caused by 20-fold preexposure (four times daily) of environmental conditional stimulus before training. For modeling of the weak latent inhibition 10-fold preexposure was used. Effects of D2 agonist quinpirole (1 mg/kg) and selective D1 agonist SKF 38393 (1 mg/kg) injected individually and in combination with haloperidol (0.5 mg/kg) were tested. Quinpirole caused a significant potentiation of the normal latent inhibition (20-fold preexposures) but did not affect the weak latent inhibition. Haloperidol reinforced the weak latent inhibition but reduced the normal latent inhibition. The agent SKF 38393 was not able to affect the latent inhibition

independently of the preexposure number. Injected in combination with haloperidol, SKF 38393 prevented the normal latent inhibition from being impaired by haloperidol. These findings suggest

that D1 receptors do not appear to participate in the Linsitinib mouse modulation of the latent inhibition as an independent substrate, but D1 receptors are essential for the full manifestation of the D2-mediated modulation of the latent inhibition.”
“Objective. – To analyze the functional and urodynamic results of a compressive sub-urethral Dinaciclib in vivo sling with bone anchoring InVance (TM).\n\nMethods. – One hundred and six successive patients were operated with this system between August 2004 and March 2009. Urinary incontinence was classified according to the number of daily protections. All the patients have benefited from a clinical, endoscopic and urodynamic pre and post-operative evaluation. The results were classified in four groups, at three months and at one year, according to whether the patients were dry (A), very improved (B), little improved (C), or with no improvement (D).\n\nResults. – The average age of the patients during the installation of the strip was 67.4 years (4682). At three months, the rate of dry (A) or

very improved patients (B) was of 81.2% (A = 75.5%; B = 5.7%), and at one year: 75.5% (A = 61%; B = 14.5%). At three months, the STA-9090 in vitro rate of patients little improved (C) or not improved (D) was of 18.8% (C = 16%; D = 2.8%), and at one year: 24.5% (C = 20.3%; D = 4.2%). These results deteriorated according to the initial rank of incontinence II, III, and I. Six patients (5.7%) were explanted because of a prosthetic infection which perished at an average of 9 months (3-18). Infection was linked to operative time (p = 0.02), and patients age. No osteitis nor urethral erosion were noted. There was a significant rise in the pressures of maximum fence at rest and maximum urethral pressures in reserve (p = 0.01). At one year, score ICIQ-UI SF decreased overall by 7.1 points.\n\nConclusion. – The medium-term results of under-urethral supporting with bone anchoring InVance (TM) are very encouraging. This technique presents an acceptable morbidity and a good tolerance.