Each CV-IB of four regions was lower in HCM patients than in controls (all P<0.01). CV-IB of the VS mid-wall layer was lower in 14 HCM patients with cardiac events than in patients without (5.4 +/- 0.6 vs. 7.4 +/- 0.5 dB, P = 0.033) although CV-IB of three other regions did not differ between the two groups. The optical cut-off point of % CV-IB <90%, i.e. the ratio of CV-IB in the VS mid-wall layer to the mean value in the layers on both sides, was an independent predictor of cardiac events

(hazard ratio, 6.12; 95% confidence interval, 1.62-66.6; P = 0.013), with a positive predictive value of 44% and particularly with a high negative predictive value of 91%.\n\nConclusion Patients with non-obstructive HCM are not likely to undergo cardiac events in the near future, when the VX-680 CV-IB value is not significantly lower in the VS mid-wall layer than in the layers on both sides.”
“Alterations of hemorheological determinants and glycated hemoglobin levels are prominent features of diabetic retinopathy,

resulting in the increased whole-blood INCB28060 purchase and plasma viscosities observed in this condition. These variables have been reported to show ethnic variations. The present study was designed to investigate the pattern of alterations in these variables and the possible influence of plasma viscosity in black diabetic retinopathy patients. Forty-two patients, who included 14 males and 28 females (mean age, 62.81 +/- 11.38 years) were studied. The control group consisted of 30 black, nondiabetic, age-matched subjects, including 10 males and 20 females. Relative plasma viscosity, plasma fibrinogen concentration, packed cell volume, and mean glycated hemoglobin were significantly check details higher in the diabetic subjects compared with the controls. We observed an increase in plasma viscosity in our study population, similar to those reported in previous studies for Caucasians.”
“The objective of present research is to examine the thermal radiation effect in three-dimensional

mixed convection flow of viscoelastic fluid. The boundary layer analysis has been discussed for flow by an exponentially stretching surface with convective conditions. The resulting partial differential equations are reduced into a system of nonlinear ordinary differential equations using appropriate transformations. The series solutions are developed through a modern technique known as the homotopy analysis method. The convergent expressions of velocity components and temperature are derived. The solutions obtained are dependent on seven sundry parameters including the viscoelastic parameter, mixed convection parameter, ratio parameter, temperature exponent, Prandtl number, Biot number and radiation parameter. A systematic study is performed to analyze the impacts of these influential parameters on the velocity and temperature, the skin friction coefficients and the local Nusselt number.

“
“The main objective of this study was to evaluate the role of the concentration of solid air-suspended selleck compound particles (SSP) in the incidence of mental disorders. The study is based on 1,871 cases, registered in the Beer-Sheva Mental Health Center (BS-MHC) at Ben-Gurion University (Israel) during a 16-month period from

2001 to 2002; 1,445 persons were hospitalized due to exacerbation of schizophrenia (ICD-10: F20-F29) and 426 after committing a suicide attempt using a variety of means as coded in the ICD-10 (ICD-10: X60-X84). Pearson and Spearman test correlations were used; the statistical significance was tested at p < 0.1. A significant correlation between variations of SSP number concentration (N (C) ) during eastern desert wind during early morning hours and number of suicide attempts, N (SU) , was found (rho > 0.3, p < 0.05), whereas correlation between N (C) and N (SU) during western air streams (sea breeze) was not observed (p > 0.2). A trend towards positive correlation (rho > 0.2, p < 0.1) between the N (C) and number of persons with exacerbation of schizophrenia as manifested in psychotic

attack (N (PS) ) in periods with dominant eastern winds (4-9 am, local time) has been observed, while in the afternoon and evening hours (1-8 pm local time) with dominant western winds, N (C) and N (PS) are not correlated (p > 0.1). Obviously, concentration of SSP is not CHIR-99021 supplier the one and only parameter of air pollution state determining meteorological-biological impact, involving incidence of mental disorders, although its role can scarcely be overstated. However, since it is one of the simplest measured parameters, it could be widely used and helpful in the daily struggle for human life comfort in semi-arid areas as well as urban and industrial surroundings, where air DNA Damage inhibitor pollution reaches crucial values. This study may permit determination of the limits for different external factors, which do

not overcome threshold values (without provoking avalanche situations), to single out the group of people at increased risk (with according degree of statistic probability), whose reactions to the weather violations can involve the outbreak of frustration points and prevent or alleviate detrimental mental effects.”
“Guanine-rich DNA sequences that may form G-quadruplexes are located in strategic DNA loci with the ability to regulate biological events. G-quadruplexes have been under intensive scrutiny owing to their potential to serve as novel drug targets in emerging anticancer strategies. Thermodynamic characterization of G-quadruplexes is an important and necessary step in developing predictive algorithms for evaluating the conformational preferences of G-rich sequences in the presence or the absence of their complementary C-rich strands.

The time to first request for local anesthetic infusion was longer in Group 1 than in Groups 2 and 3 (P < 0.001). The median morphine consumption during the first 24 postoperative hours was less in Groups 1 and 2 than in Group 3 (P < 0.001). There was no significant difference in analgesic consumption between Group 1 and Group 2. The median satisfaction score was higher in Group 1 compared with Groups 2 (P < 0.05) and 3 (P < 0.001).\n\nCONCLUSIONS: A combination of intraarticular ropivacaine,

morphine, and ketorolac followed by intermittent injections of ropivacaine as needed provided better pain relief, less morphine consumption, and improved see more patient satisfaction compared with the control group. The selleck chemicals llc group that received IV ketorolac consumed less morphine and was more satisfied with treatment than patients in the control group.”
“Aim: To retrospectively analyze the long-term toxicities of low-dose-rate interstitial brachytherapy (LDR-BT) with related prognostic factors for patients with early mobile tongue cancer (T1/2N0M0) at a minimum of 10 years’ follow-up. Patients and Methods: The records of 187 patients treated with LDR-BT between 1980 and 2000, out of whom 25

were treated with additional prior external beam irradiation, were reviewed. Results: Overall survival at 15 and 20 years was 88.4% and 76.2%, respectively. Complications included tongue ulcer (26%), tongue erosion (3%), tongue atrophy (2%), bone exposure (15%), and osteoradionecrosis (4%). No patient presented xerostomia or taste disorders. Multivariate analysis revealed that tongue ulcer and the use of spacer were significantly associated with bone exposure and osteoradionecrosis. Local recurrence was demonstrated in 15 (8%) cases, 93% of which were salvaged by operation. Fifty patients

(27%) experienced neck metastasis. Conclusion: LDR-BT is an acceptable treatment option, with low rates of long-term Selleckchem Crenigacestat toxicity.”
“We studied the profiles of thyroid hormone receptors (TRs) in Japanese eels (Anguilla japonica) during development from hatched larvae to juveniles. Two TR alpha s (TR alpha A and TR alpha B)and one TR beta (TR beta A) cDNA clones were generated by RACE. The TR alpha A, TR alpha B and TR beta A cDNAs encoded 416,407 and 397 amino acid proteins with much higher homologies to the Japanese conger eel (Conger myriaster) TRs than to other fish TRs. In a transiently transfected Japanese eel cell line, Hepa-E1, the TRs showed thyroid hormone (TH)-dependent activation of transcription from the TH-responsive promoter. Four TR cDNA clones, including TR beta B reported in a previous study, were analyzed by real-time RT-PCR. The TR mRNA levels in hatched larvae were determined. The two TR beta mRNAs were present at low levels but there was a peak in the TR alpha s during the larval stage before metamorphosis. During metamorphosis, the two TR alpha s both exhibited peaks and expression of the two TR beta s was higher than during the early growth stage.

The results revealed that the gilts expressed first observed

estrus, averagely, at age 205.1 +/- 34.1 days, had a growth rate of 615.5 +/- 57.6 g/day, and first contact with boars at 160.7 +/- 19.9 days of age. The gilts with low growth rate expressed first estrus later than those with moderate (208.6 +/- 2.0 vs 198.0 +/- 3.2 days, P = 0.033) and high growth rate (208.6 +/- 2.0 vs 193.9 +/- 6.7 days, P = 0.005) groups. Together with the influence of boar exposure, the gilts contacted boar earlier with high growth rate showed first estrus at age 180.3 +/- 10.1 days, whereas those with later boar contact with low growth rate showed first estrus at age 197.9 +/- 3.2 days. In summary, the replacement gilts should have high growth rate and contact AZD6094 cell line boar early to attain puberty faster CHIR98014 order and possess decent subsequent reproductive performance.”
“Both target radiofrequency thermocoagulation and collagenase chemonucleolysis are effective micro-invasive therapy means for lumbar intervertebral disc herniation. In order to analyze the clinical effects of target radiofrequency

thermocoagulation combined with collagenase chemonucleolysis on lumbar intervertebral disc herniation, the contents of hydroxyproline and glycosaminoglycan were measured and the histological changes of nucleus pulposus was detected in the vitro experiments. Radiofrequency thermocoagulation reduced the hydrolyzation of herniated nucleus pulposus caused by collagenase, as well as the content of hydroxyproline and glycosaminoglycan. Furthermore, 236 patients with lumbar intervertebral disc herniation were treated by target radiofrequency thermocoagulation combined with collagenase chemonucleolysis. The efficiency was evaluated according to Macnab criteria, and the index of lumbar disc herniation (IDH) was compared pre-operation with 3 months post-operation. The post-operative good rate was 66.5% (157/236) at 2 weeks post-operation,

and 88.1% (208/236) at 3 months post-operation. In the post-operative follow-up exam, 86.8% AZD1480 of the re-examined cases demonstrated smaller or ablated protrusion, with reduced IDH values from pre-operation, which was statistically significant. No serious complications were detected intra-operatively and post-operatively. In conclusion, target radiofrequency combined with collagenase chemonucleolysis was an effective and safe method for treatment of lumbar intervertebral disc herniation.”
“To date, the structures of the sucrose tetraester (STE) isomers, a main kind of sucrose esters (SEs) in Solanum, have not been conclusively assigned. In this study, three groups of STE isomers with the molecular weight 650, 664 and 678 (designated as STE I, STE II and STE III, respectively) have been isolated and purified from the oriental tobacco-Komotini Basma using a semi-preparative RP-HPLC method.

We observed a slightly higher increase in forced expiratory volume in 1 second in the SIT5 group compared with the SIT3 group.\n\nConclusion: Three years of SIT is an adequate duration for the treatment of childhood asthma associated with HDM allergy because 2 further years of SIT added no clinical benefit. (C) 2012 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.”
“Atopic dermatitis (AD) is easily aggravated by detergents, synthetic and woollen clothing, and bacterial colonization. Cotton clothing is often recommended for children with AD, but cotton can contain rough fibres that may act as skin irritants. In contrast, silk is characterized by

smooth fibres with minimal potential for irritation. We report a sericin-free silk (DermaSilk (R)), which is treated with AEGIS AEM5772/5, a product that has antibacterial properties, and evaluate its use https://www.selleckchem.com/products/nct-501.html in the treatment of AD.”
“Aim. – Congenital diaphragmatic hernia (CDH) is a rare disease (1/3000 live births). Carriers display a diaphragmatic defect responsible for an impaired pulmonary development and physiology. The aim of this study was to evaluate the information given to couples whose fetus display a CDH and the current knowledge of French sonographers about this disease.\n\nMaterials and methods. – A questionnaire was sent by email to 2000 sonographers, members of the French college of fetal uttrasonography, between find more May 1st and December 31st of 2010.\n\nResults. – 20,7% (414) of the sonographers answered. Twenty-four percent are second line sonographers. Thirty-eight percent did not diagnose any diaphragmatic hernia in the last five years (2005-2010) and 42% diagnosed 1 or 2 during the same period. Information concerning the prognostic remains elusive and most sonographers rapidly referred patients to prenatal diagnostic

centers. Fifty-nine percent of sonographer are not aware of the existence in France of a Centre for Rare Disease for CDH.\n\nConclusion. – Accurate assessment of prognosis is essential to provide adequate information to couples Selonsertib in vitro and to help them make a decision on whether or not to perform an in utero treatment. The heterogenous results of the survey clearly show the disparities between sonographers on the type of information delivered. A better diffusion of prognostic evaluation in CDH, among sonographers is needed. (C) 2013 Elsevier Masson SAS. All rights reserved.”
“The aim of this study was to estimate the prevalence of non-adherence to several continuous-use drugs by patients 30 to 79 years of age with self-reported hypertension, and associated factors, drawing on data from the Brazilian National Sample Household Survey (PNAD-2008). Prevalence ratios (PR) and respective 95% confidence intervals (95% CI) were obtained by Poisson regression.

When applied to a pilot line consisting of 100 workers, the intervention-reduced work related accidents in 80%, absenteeism in 45.65%, and eliminated work related musculoskeletal disorders (WMSD), medical consultations, and turnover. Further, the output rate of the multifunctional team increased average 3% compared to the production rate of the regular lines following the Taylor/Ford system

(with the same shoe model being manufactured), while the rework and spoilage rates were reduced 85% and 69%, respectively. Raf inhibitor (C) 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.”
“A 74 year old lady presented with difficulty in breathing and hypoxia. She was initially treated as pulmonary embolism (PE). However, confirmatory tests did not suggest the diagnosis of PE. Further tests gave the diagnosis of an ovarian carcinoid presenting with shortness of breath and hypoxia. After an PF-00299804 Protein Tyrosine Kinase inhibitor initial treatment with Octreotide. she underwent salpingo-oophorectomy.\n\nShe became asymptomatic and made an uneventful recovery. Ovarian carcinoids can produce carcinoid syndrome without the presence of hepatic metastases. Here we provide a short review on ovarian carcinoids.”
“Rapid and accurate detection of Streptococcus pneumoniae

(Sp), Haemophilus influenzae type b (Hib) and Mycobacterium tuberculosis complex (MTBC) in sputum by conventional methods remains problematic. Primers based on capsular polysaccharide biosynthesis gene (cpsA), the region II of the

capsulation locus (cap), the insertion sequence IS6110 were designed for Sp, Hib, MTBC respectively. These primers were incorporated in a multiplex touchdown PCR assay for simultaneous detection of Sp, Hib and MTBC. The multiplex touchdown PCR assay was evaluated using standard strains and clinical sputum samples. The multiplex touchdown PCR assay showed 100% find more specificity in identifying Sp, Hib, MTBC from pure culture of standard strains. The sensitivities of the multiplex touchdown PCR assay were 94%, 98%, 98% for detection of Sp, Hib and MTBC respectively based on culture results while evaluated using 492 consecutive qualified clinical sputum samples; the specificities were all 100%. This highly sensitive and specific multiplex touchdown PCR assay offers a rapid and simple method for detection of Sp, Hib and MTBC in clinical sputum samples.”
“Renal artery stenting is expected to improve or stabilize renal function. However, the efficacy of renal artery stenting in severely reduced renal function is unclear. We evaluated 23 patients with class IV or V renal dysfunction who were treated for renal artery stenosis between 2004 and 2009. Improvement in renal function was found in 7 (30%) patients, all of whom were treated with distal protection device. Deterioration of renal function was found in 4 (17%) cases. In these 4 cases, distal protection device could not be used for anatomical reasons.

Overall median survival was histology specific (osteosarcoma, 11 months; Ewing sarcoma, 26 months; chondrosarcoma, 37 months; chordoma, 50 months) and correlated with extent of local tissue invasion or metastasis at presentation. Presence of metastasis was associated with marked decrease in survival (P < 0.001) for all tumor types. For patients with isolated spine tumors, neoplasms confined within the periosteum were associated with improved overall survival independent of age, radiotherapy, or surgical resection for chordoma (hazard ratio [HR], 0.50; P = 0.08), chondrosarcoma

(HR, 0.62; P = 0.03), GSK923295 in vivo and osteosarcoma (HR, 0.68; P = 0.05), but not Ewing sarcoma (HR, 0.62; P = 0.27).\n\nCONCLUSIONS: The preoperative radiographic recognition of local tissue invasion

may identify patients with a more aggressive tumor and help guide the level of aggressiveness in subsequent treatment strategies.”
“A 74-year-old right-handed woman without cognitive impairment suddenly developed nonfluent aphasia. Brain MRI showed acute infarction in the right frontal lobe and insula without involvement of the corpus callosum. A neurological examination demonstrated not only transcortical motor aphasia, but also ideomotor apraxia and right hand predominant constructional apraxia (CA). To date, right hand selleck chemicals predominant CA has only been reported in patients with corpus callosum lesions. The right hand predominant CA observed in our patient may be associated with the failure to transfer information on the spatial structure from the right hemisphere to the motor cortex of the left hemisphere.”
“gamma-Secretase is an intramembrane-cleaving protease responsible for the generation of amyloid-beta (A beta) peptides. Recently, a series of compounds called.-secretase modulators (GSMs) has been shown to decrease the levels of long toxic A beta species

(i.e., A beta 42), with a concomitant elevation of the production of shorter A beta species. In this study, we show that a phenylimidazole-type Cell Cycle inhibitor GSM allosterically induces conformational changes in the catalytic site of.-secretase to augment the proteolytic activity. Analyses using the photoaffinity labeling technique and systematic mutational studies revealed that the phenylimidazole-type GSM targets a previously unidentified extracellular binding pocket within the N-terminal fragment of presenilin (PS). Collectively, we provide a model for the mechanism of action of the phenylimidazole-type GSM in which binding at the luminal side of PS induces a conformational change in the catalytic center of.-secretase to modulate A beta production.”
“Background Obesity increases the risk of cancer death among postmenopausal women with estrogen receptor-positive (ER+) breast cancer, but the direct evidence for the mechanisms is lacking.

05). The results expand the knowledge on use of medications among elderly Brazilians, emphasizing the need to improve pharmaceutical care focused on this subgroup of the population.”
“Background aims. Donor-derived vertebral bone marrow (BM) has been proposed to promote chimerism in solid organ transplantation with cadaveric organs. Reports of successful weaning

from immunosuppression in patients receiving directed donor transplants in combination with donor BM or blood cells and novel peri-transplant immunosuppression has renewed interest in implementing similar protocols with cadaveric organs. Methods. We performed six pre-clinical full-scale separations to adapt vertebral BM preparations to a good manufacturing practice (GMP) environment. Vertebral bodies L4-T8 were transported to a class 10 000 clean room, cleaned of soft selleck screening library tissue, divided and crushed in a prototype bone grinder. Bone

fragments were irrigated with medium containing saline, albumin, DNAse and gentamicin, and strained through stainless steel sieves. Additional cells were eluted after two rounds of agitation using a prototype BM tumbler. Results. The majority of recovered cells (70.9 +/- 14.1%, mean +/- SD) were eluted directly from the crushed bone, whereas DMH1 datasheet 22.3% and 5.9% were eluted after the first and second rounds of tumbling, respectively. Cells were pooled and filtered (500, 200 mu m) using a BM collection kit. Larger lumbar vertebrae yielded about 1.6 times the cells of thoracic vertebrae. The average product yielded 5.2 +/- 1.2 x 10(10) total cells, 6.2 +/- 2.2 x 10(8) of which were CD45(+) CD34(+). Viability was 96.6 +/- 1.9% and 99.1 +/- 0.8%, respectively. Multicolor flow cytometry revealed distinct populations of CD34(+) CD90(+) CD117(dim) hematopoietic stem cells (15.5 +/- 7.5% of the CD34(+) cells) and

CD45(-) MLN4924 cost CD73(+) CD105(+) mesenchymal stromal cells (0.04 +/- 0.04% of the total cells). Conclusions. This procedure can be used to prepare clinical-grade cells suitable for use in human allotransplantation in a GMP environment.”
“The cytopathologic diagnosis of basaloid squamous cell carcinoma can be problematic as there are several components of the differential diagnosis that share common cytomorphologic features. In this study, we report the fine-needle aspiration (FNA) findings of 16 basaloid squamous cell carcinoma cases and compare those cases to 16 cases of small cell carcinoma. To our knowledge, this is the largest series of basaloid squamous cell carcinoma FNA cases ever reported. The following cytomorphologic features were compared for both tumors: cohesive tissue fragments, single cells, adenoid cystic-like features (cribriform pseudoglandular lumina with hyaline materials), necrosis, nuclear size, nuclear molding, nucleoli, cytoplasm, and the presence of single keratinized cells.

campestris, the highest xanthan concentration (16.4 g/L) was achieved at 65.2 g/L of cheese whey (39.1 g/L of lactose), 14.8 g/L of phosphate (K H2PO4), and 1.1 g/L of

magnesium (MgSO4 center dot 7H(2)O). The corresponding optimum cheese whey, phosphate, Selleckchem Sapanisertib and magnesium concentrations in cultures of X. pelargonii were 80.0, 6.7, and 0.8 g/L, respectively, which resulted in a xanthan production of 12.8 g/L. The xanthan gum yield (g of xanthan/g of lactose) was 0.42 for X. campestris and 0.27 for X. pelargonii.”
“Background and purpose: The contribution of endothelin-1 (ET-1) to vascular hyper-reactivity associated with chronic ethanol intake, a major risk factor in several cardiovascular diseases, remains to be investigated.\n\nExperimental approach: The biphasic haemodynamic responses to ET-1 (0.01-0.1 nmol kg(-1), i.v.) or to the selective ET(B) agonist, IRL1620 (0.001-1.0 nmol kg(-1), i.v.), with or without ET(A) or ET(B) antagonists (BQ123 (c(DTrp-Dasp-Pro-Dval-Leu)) at 1 and 2.5 mg kg(-1) and BQ788 (N-cis-2,6-dimethyl-piperidinocarbonyl-L-gamma-methylleucyl1-D-1methoxycarbonyltryptophanyl-D-norleucine) at

0.25 mg kg(-1), respectively) were tested in anaesthetized rats, after 2 weeks’ chronic ethanol treatment. Hepatic parameters and ET receptor protein levels were also determined.\n\nKey results: The initial hypotensive responses to ET-1 or IRL1620 were unaffected by chronic ethanol VX-680 datasheet intake, whereas the subsequent

pressor effects induced by ET-1, but not by IRL1620, were potentiated. BQ123 at 2.5 but not 1 mg kg(-1) reduced the pressor responses to ET-1 in ethanol-treated rats. Conversely, BQ788 (0.25 mg kg(-1)) potentiated buy Kinase Inhibitor Library ET-1-induced increases in mean arterial blood pressure in control as well as in ethanol-treated rats. Interestingly, in the latter group, increases in heart rate, induced by ET-1 at a dose of 0.025 mg kg(-1) were enhanced following ET(B) receptor blockade. Finally, we observed higher levels of ET(A) receptor in the heart and mesenteric artery and a reduction of ET(B) receptor protein levels in the aorta and kidney from rats chronically treated with ethanol.\n\nConclusions and implications: Increased vascular reactivity to ET-1 and altered protein levels of ET(A) and ET(B) receptors could play a role in the pathogenesis of cardiovascular complications associated with chronic ethanol consumption.”
“Mixed epithelial and stromal tumors (MESTs) of the kidney are rare renal neoplasms characterized by mixed cystic and solid components. These tumors are typically present in middle-aged women as a flank mass, or as a cause of flank pain or hematuria. We outline the case of an older male who presented with an enlarging abdominal mass causing symptoms that suggested a partial small bowel obstruction. Management of the patient and a brief review are discussed.

The fertility parameters were determined to be as https://www.selleckchem.com/ALK.html follows: heat rate, pregnancy rate, parturition rate, single-born rate, twinning rate, abortion rate, lamb rate, and number of lambs per parturition,

based on the number of ewes assigned for mating, were 100%, 93.8%, 90.5%, 79.7%, 20.3%, 1.4%, 108.8%, and 1.20%, respectively. The survival rates of lambs at 60 and 120 days of age were 88.3% and 84.5%, respectively. The average lactation milk yield and lactation period of the Awassi ewes were 196.5 +/- 5.60 kg and 184.3 +/- 2.11 days, respectively. The general death and slaughter rate of the stock was 8.2% throughout the research period. The lactation milk yield was affected by the production year (P < 0.01) and the age of the ewe (P < 0.01), but the lactation length was not affected by the same

environmental factors (P > 0.05). The results of this study have shown that the Awassi sheep raised in the Central Anatolian Region had similar lactation milk yield, fertility parameters, and survival rates as the Awassi sheep’s original race. In addition, since there were no epidemic health problems observed during the 2-year research period, Awassi BVD-523 in vivo sheep were shown to be adapted to being raised in this region.”
“Ecological fingerprints of climate change are becoming increasingly evident at broad geographical scales as measured by species range shifts and changes in phenology. However, finer-scale species-level responses to environmental fluctuations may also provide an important bellwether of impending future community responses. Here we examined changes in abundance of butterfly species along a hydrological BMS-345541 inhibitor gradient of six montane meadow habitat types in response to drought. Our data collection began prior to the drought, and we were able to track

changes for 11 years, of which eight were considered mild to extreme drought conditions. We separated the species into those that had an affinity for hydric vs. xeric habitats. We suspected that drought would favor species with xeric habitat affinities, but that there could be variations in species-level responses along the hydrological gradient. We also suspected that mesic meadows would be most sensitive to drought conditions. Temporal trajectories were modeled for both species groups (hydric vs. xeric affinity) and individual species. Abundances of species with affinity for xeric habitats increased in virtually all meadow types. Conversely, abundances of species with affinity for hydric habitats decreased, particularly in mesic and xeric meadows. Mesic meadows showed the most striking temporal abundance trajectory: Increasing abundances of species with xeric habitat affinity were offset by decreasing or stable abundances of species with hydric habitat affinity.